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  High-resolution myocardial T1 mapping using single-shot inversion-recovery fast low-angle shot MRI with radial undersampling and iterative reconstruction.

Wang, X., Joseph, A. A., Kalentev, O., Merboldt, K. D., Voit, D., Roeloffs, V. B., et al. (2016). High-resolution myocardial T1 mapping using single-shot inversion-recovery fast low-angle shot MRI with radial undersampling and iterative reconstruction. British Journal of Radiology, 89(1068): 20160255. doi:10.1259/bjr.20160255.

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 Creators:
Wang, X.1, Author           
Joseph, A. A.1, Author           
Kalentev, O.1, Author           
Merboldt, K. D.1, Author           
Voit, D.1, Author           
Roeloffs, V. B.1, Author           
van Zalk, M.1, Author           
Frahm, J.1, Author           
Affiliations:
1Biomedical NMR Research GmbH, MPI for Biophysical Chemistry, Max Planck Society, ou_578634              

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 Abstract: To develop a novel method for rapid myocardial T1 mapping at high spatial resolution. METHODS: The proposed strategy represents a single-shot inversion-recovery (IR) experiment triggered to early diastole during a brief breathhold. The measurement combines an adiabatic inversion pulse with a real-time readout by highly undersampled radial FLASH, iterative image reconstruction and T1 fitting with automatic deletion of systolic frames. The method was implemented on a 3 T MRI system using a GPU-equipped bypass computer for online application. Validations employed a T1 reference phantom including analyses at simulated heart rates from 40 to 100 bpm. In vivo applications involved myocardial T1 mapping in short-axis views of healthy young volunteers. RESULTS: At 1 mm in-plane resolution and 6 mm section thickness, the IR measurement could be shortened to 3 s without compromising T1 quantitation. Phantom studies demonstrated T1 accuracy and high precision for values ranging from 300 to 1500 ms and up to a heart rate of 100 bpm. Similar results were obtained in vivo yielding septal T1 values of 1246 ± 24 ms (base), 1256 ± 33 ms (mid-ventricular) and 1288 ± 30 ms (apex), respectively (mean ± SD, n=6). CONCLUSION: Diastolic myocardial T1 mapping with use of single-shot inversion-recovery FLASH offers high spatial resolution, T1 accuracy and precision, practical robustness and speed. Advances in knowledge: The proposed method will be beneficial for clinical applications relying on native and post-contrast T1 quantitation.

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Language(s): eng - English
 Dates: 2016-11-182016-12
 Publication Status: Issued
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 Rev. Type: Peer
 Identifiers: DOI: 10.1259/bjr.20160255
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Title: British Journal of Radiology
Source Genre: Journal
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Pages: 8 Volume / Issue: 89 (1068) Sequence Number: 20160255 Start / End Page: - Identifier: -