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  Carbohydrate-glycolipid conjugate vaccines

Seeberger, P. H., Stallforth, P., Delibero, G., & Cavallari, M.(2013). Carbohydrate-glycolipid conjugate vaccines.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-037E-B Version Permalink: https://hdl.handle.net/21.11116/0000-0006-5A27-A
Genre: Patent

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2364258.pdf (Publisher version), 5MB
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 Creators:
Seeberger, Peter H.1, Author           
Stallforth, Pierre2, Author           
Delibero, Gennaro, Author
Cavallari, Marco, Author
Affiliations:
1Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863308              
2Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863286              

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 Abstract: The present invention relates to the field of synthesizing and biologically evaluating of a novel class of carbohydrate-based vaccines. The new vaccines consist of a multi-modular structure wherein a carbohydrate antigen is covalently bound to a glycolipid adjuvant. This method allows preparing vaccines against all pathogens expressing immunogenic carbohydrate antigens. As conjugation of antigenic carbohydrates to proteins is not required the conjugate vaccine is particularly heat stable. No refrigeration is required, a major drawback of protein-based vaccines.

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 Dates: 2012-05-262013-12-05
 Publication Status: Published online
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 Identifiers: Patent Publication Nr.: WO2013178236 A1
Patent Application Nr.: PCT/EP2012/002277
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