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  Total synthesis and immunological evaluation of saccharide moieties of the lipopolysaccharide from neisseria meningitidis
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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-03F3-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-6455-0
Genre: Patent

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2364340.pdf (Publisher version), 8MB
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 Creators:
Seeberger, Peter H.1, Author              
Yang, You2, Author              
Chakkumkal, Anish3, Author              
Reinhardt, Anika3, Author              
Affiliations:
1Peter H. Seeberger, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2040285              
2Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863306              
3Chakkumal Anish, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863299              

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 Abstract: The present invention relates to the total chemical synthesis of the monosaccharide 35# (R'-H), the disaccharide 36# (R'<>H; R''-H), the trisaccharide 37# (R'<>H; R''<>H; R'''<>H) and the tetrasaccharide 1# (R'<>H; R''<>H; R'''<>H) of the following general formula wherein R represents -Y-NH2Y represents a linker R' is H or R'' is H or R''' is H or of the lipopolysaccharide from Neisseria meningitidis, as well as to the trisaccharide 37# and the tetrasaccharide 1#, to vaccines containing at least one of the saccharides 1#, 35#, 36#, and 37# and to the use of such vaccine for immunization against diseases caused by infection with bacteria containing the tetrasaccharide [alpha]-GlcNAc-(1->2)-[alpha]-Hep-(1->3)-[alpha]-Hep-(1->5)-[alpha]-Kdo or the trisaccharide [alpha]-Hep-(1->3)-[alpha]-Hep-(1->5)-[alpha]-Kdo or [alpha]-GlcNAc-(1->2)-[alpha]-Hep-(1->3)-[alpha]-Hep, especially for immunization against meningitis, septicaemia, pneumonia and nasopharyngitis caused by Neisseria meningitidis.

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 Dates: 2012-09-242014-08-21
 Publication Status: Published online
 Pages: -
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 Identifiers: Patent Publication Nr.: US20140234364 A1
Patent Application Nr.: US201214346858 20120924
Patent Nr.: EP2766024 A1
Patent Nr.: WO 2013041732 A1
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