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  Nanoparticle tension probes patterned at the nanoscale: impact of integrin clustering on force transmission

Liu, Y., Medda, R., Liu, Z., Galior, K., Yehl, K., Spatz, J. P., et al. (2014). Nanoparticle tension probes patterned at the nanoscale: impact of integrin clustering on force transmission. Nano Letters, 14(10), 5539-5546. doi:10.1021/nl501912g.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-30DF-0 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002E-5F9E-E
Genre: Journal Article

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 Creators:
Liu, Yang, Author
Medda, Rebecca1, 2, Author           
Liu, Zheng, Author
Galior, Kornelia, Author
Yehl, Kevin, Author
Spatz, Joachim P.1, 2, Author           
Cavalcanti-Adam, Elisabetta Ada1, 2, Author           
Salaita, Khalid, Author
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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Free keywords: Nanopatterning; focal adhesion; integrin; mechanotransduction; molecular tension fluorescence microscopy; receptor clustering
 Abstract: Herein we aimed to understand how nanoscale clustering of RGD ligands alters the mechano-regulation of their integrin receptors. We combined molecular tension fluorescence microscopy with block copolymer micelle nanolithography to fabricate substrates with arrays of precisely spaced probes that can generate a 10-fold fluorescence response to pN-forces. We found that the mechanism of sensing ligand spacing is force-mediated. This strategy is broadly applicable to investigating receptor clustering and its role in mechanotransduction pathways.

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Language(s): eng - English
 Dates: 2014-08-292014-05-222014-09-192014-09-302014-09-19
 Publication Status: Issued
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1021/nl501912g
URI: https://www.ncbi.nlm.nih.gov/pubmed/25238229
URI: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189618/
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Title: Nano Letters
  Abbreviation : Nano Lett.
Source Genre: Journal
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Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 14 (10) Sequence Number: - Start / End Page: 5539 - 5546 Identifier: ISSN: 1530-6984
CoNE: https://pure.mpg.de/cone/journals/resource/110978984570403