English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Nanoparticle tension probes patterned at the nanoscale: impact of integrin clustering on force transmission

Liu, Y., Medda, R., Liu, Z., Galior, K., Yehl, K., Spatz, J. P., et al. (2014). Nanoparticle tension probes patterned at the nanoscale: impact of integrin clustering on force transmission. Nano Letters, 14(10), 5539-5546. doi:10.1021/nl501912g.

Item is

Files

show Files
hide Files
:
NanoLett_14_2014_5539.pdf (Any fulltext), 10MB
 
File Permalink:
-
Name:
NanoLett_14_2014_5539.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
NanoLett_14_2014_5539_Suppl.pdf (Supplementary material), 3MB
 
File Permalink:
-
Name:
NanoLett_14_2014_5539_Suppl.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-
Locator:
http://pubs.acs.org/doi/suppl/10.1021/nl501912g (Supplementary material)
Description:
-
Locator:
https://dx.doi.org/10.1021/nl501912g (Any fulltext)
Description:
-

Creators

show
hide
 Creators:
Liu, Yang, Author
Medda, Rebecca1, 2, Author              
Liu, Zheng, Author
Galior, Kornelia, Author
Yehl, Kevin, Author
Spatz, Joachim P.1, 2, Author              
Cavalcanti-Adam, Elisabetta Ada1, 2, Author              
Salaita, Khalid, Author
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

Content

show
hide
Free keywords: Nanopatterning; focal adhesion; integrin; mechanotransduction; molecular tension fluorescence microscopy; receptor clustering
 Abstract: Herein we aimed to understand how nanoscale clustering of RGD ligands alters the mechano-regulation of their integrin receptors. We combined molecular tension fluorescence microscopy with block copolymer micelle nanolithography to fabricate substrates with arrays of precisely spaced probes that can generate a 10-fold fluorescence response to pN-forces. We found that the mechanism of sensing ligand spacing is force-mediated. This strategy is broadly applicable to investigating receptor clustering and its role in mechanotransduction pathways.

Details

show
hide
Language(s): eng - English
 Dates: 2014-08-292014-05-222014-09-192014-09-302014-09-19
 Publication Status: Published in print
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Nano Letters
  Abbreviation : Nano Lett.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 14 (10) Sequence Number: - Start / End Page: 5539 - 5546 Identifier: ISSN: 1530-6984
CoNE: https://pure.mpg.de/cone/journals/resource/110978984570403