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  Fine tuning and efficient T cell activation with stimulatory aCD3 nano-arrays

Matic, J., Deeg, J., Scheffold, A., Goldstein, I., & Spatz, J. P. (2013). Fine tuning and efficient T cell activation with stimulatory aCD3 nano-arrays. Nano Letters, 13(11), 5090-5097. doi:10.1021/nl4022623.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0015-1009-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-77CE-C
Genre: Journal Article

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 Creators:
Matic, Jovana1, 2, Author              
Deeg, Janosch1, 2, Author              
Scheffold, Alexander, Author
Goldstein, Itamar, Author
Spatz, Joachim P.1, 2, Author              
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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Free keywords: anti-CD3 monoclonal antibody; Artificial antigen presenting interfaces; block copolymer micellar nanolithography (BCML); CD4+ T cells; nanopattern; T cell activation
 Abstract: Anti-CD3 (aCD3) nanoarrays fabricated by self-assembled nanopatterning combined with site-directed protein immobilization techniques represent a novel T cell stimulatory platform that allows tight control over ligand orientation and surface density. Here, we show that activation of primary human CD4+ T cells, defined by CD69 upregulation, IL-2 production and cell proliferation, correlates with aCD3 density on nanoarrays. Immobilization of aCD3 through nanopatterning had two effects: cell activation was significantly higher on these surfaces than on aCD3-coated plastics and allowed unprecedented fine-tuning of T cell response.

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Language(s): eng - English
 Dates: 2013-10-032013-06-202013-10-102013
 Publication Status: Published in print
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1021/nl4022623
 Degree: -

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Title: Nano Letters
Source Genre: Journal
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Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 13 (11) Sequence Number: - Start / End Page: 5090 - 5097 Identifier: ISSN: 1530-6984
CoNE: https://pure.mpg.de/cone/journals/resource/110978984570403