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  A quantitative 3D motility analysis of trypanosoma brucei by use of digital in-line holographic microscopy

Weiße, S., Heddergott, N., Heydt, M., Pflästerer, D., Maier, T., Haraszti, T., et al. (2012). A quantitative 3D motility analysis of trypanosoma brucei by use of digital in-line holographic microscopy. PLoS One, 7(5): e37296, pp. 1-13. doi:10.1371/journal.pone.0037296.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-4B92-7 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002E-7F6D-2
Genre: Journal Article

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http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0037296&type=printable (Any fulltext)
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http://dx.doi.org/10.1371/journal.pone.0037296 (Any fulltext)
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 Creators:
Weiße, Sebastian, Author
Heddergott, Niko, Author
Heydt, Matthias, Author
Pflästerer, Daniel, Author
Maier, Timo1, 2, Author           
Haraszti, Tamás1, 2, Author           
Grunze, Michael1, Author           
Engstler, Markus, Author
Rosenhahn, Axel, Author
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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 Abstract: We present a quantitative 3D analysis of the motility of the blood parasite Trypanosoma brucei. Digital in-line holographic microscopy has been used to track single cells with high temporal and spatial accuracy to obtain quantitative data on their behavior. Comparing bloodstream form and insect form trypanosomes as well as mutant and wildtype cells under varying external conditions we were able to derive a general two-state-run-and-tumble-model for trypanosome motility. Differences in the motility of distinct strains indicate that adaption of the trypanosomes to their natural environments involves a change in their mode of swimming.

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Language(s): eng - English
 Dates: 2012-02-222012-04-172012-05-222012-05-22
 Publication Status: Issued
 Pages: 13
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 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 611340
DOI: 10.1371/journal.pone.0037296
URI: https://www.ncbi.nlm.nih.gov/pubmed/22629379
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Title: PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 7 (5) Sequence Number: e37296 Start / End Page: 1 - 13 Identifier: ISSN: 1932-6203
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000277850