English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse
  1. Start / 
  2. Item Summary

Item

ITEM ACTIONSEXPORT
Add to Basket
  Local TagsRelease HistoryDetailsSummary

Released
Journal Article

A quantitative 3D motility analysis of trypanosoma brucei by use of digital in-line holographic microscopy

MPS-Authors
/persons/resource/persons75812

Maier,  Timo
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany;

/persons/resource/persons75557

Haraszti,  Tamás
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany;

/persons/resource/persons211638

Grunze,  Michael
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

External Resource

http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0037296&type=printable
(Any fulltext)

http://dx.doi.org/10.1371/journal.pone.0037296
(Any fulltext)

Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Weiße, S., Heddergott, N., Heydt, M., Pflästerer, D., Maier, T., Haraszti, T., et al. (2012). A quantitative 3D motility analysis of trypanosoma brucei by use of digital in-line holographic microscopy. PLoS One, 7(5): e37296, pp. 1-13. doi:10.1371/journal.pone.0037296.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-4B92-7
Abstract
We present a quantitative 3D analysis of the motility of the blood parasite Trypanosoma brucei. Digital in-line holographic microscopy has been used to track single cells with high temporal and spatial accuracy to obtain quantitative data on their behavior. Comparing bloodstream form and insect form trypanosomes as well as mutant and wildtype cells under varying external conditions we were able to derive a general two-state-run-and-tumble-model for trypanosome motility. Differences in the motility of distinct strains indicate that adaption of the trypanosomes to their natural environments involves a change in their mode of swimming.