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  Impact of local versus global ligand density on cellular adhesion

Deeg, J. A., Louban, I., Aydin, D., Selhuber-Unkel, C., Kessler, H., & Spatz, J. P. (2011). Impact of local versus global ligand density on cellular adhesion. Nano Letters, 11(4), 1469-1476. doi:10.1021/nl104079r.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-4D92-8 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002E-7B9E-5
Genre: Journal Article

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http://pubs.acs.org/doi/pdf/10.1021/nl104079r (Any fulltext)
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 Creators:
Deeg, Janosch A.1, 2, Author           
Louban, Ilia1, Author           
Aydin, Daniel1, Author           
Selhuber-Unkel, Christine1, Author           
Kessler, Horst, Author
Spatz, Joachim P.1, 2, Author           
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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Free keywords: biointerfaces; ECM; focal adhesion; Integrin; micronanostructures; single cell force spectroscopy (SCFS)
 Abstract: α(v)β(3) integrin-mediated cell adhesion is crucially influenced by how far ligands are spaced apart. To evaluate the impact of local ligand density versus global ligand density of a given surface, we used synthetic micronanostructured cell environments with user-defined ligand spacing and patterns to investigate cellular adhesion. The development of stable focal adhesions, their number, and size as well as the cellular adhesion strength proved to be influenced by local more than global ligand density.

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Language(s): eng - English
 Dates: 2010-02-202010-11-232011-03-222011-04-13
 Publication Status: Issued
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 562770
DOI: 10.1021/nl104079r
URI: https://www.ncbi.nlm.nih.gov/pubmed/21425841
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Title: Nano Letters
  Abbreviation : Nano Lett.
Source Genre: Journal
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Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 11 (4) Sequence Number: - Start / End Page: 1469 - 1476 Identifier: ISSN: 1530-6984
CoNE: https://pure.mpg.de/cone/journals/resource/110978984570403