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  Applying microdroplets as sensors for label-free detection of chemical reactions

Hofmann, T. W., Hänselmann, S., Janiesch, J.-W., Rademacher, A., & Böhm, C. H. J. (2012). Applying microdroplets as sensors for label-free detection of chemical reactions. Lab on a Chip, 12(5), 916-922. doi:10.1039/c2lc20971c.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-4B24-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-7D62-A
Genre: Journal Article

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LabChip_12_2012_916.pdf (Any fulltext), 660KB
 
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 Creators:
Hofmann, Tobias W.1, 2, Author              
Hänselmann, Siegfried, Author
Janiesch, Jan-Wilhelm1, 2, Author              
Rademacher, Anne, Author
Böhm, Christian H. J.1, 2, Author              
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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 Abstract: Despite its tremendous high-throughput screening capabilities, widespread applications of droplet-based microfluidics are still limited by the poor availability of appropriate analytical assays. Here we report on a novel sensor method that exploits the osmosis-driven change in droplet size as a quantitative and label-free marker for reactions inside the droplets. We present an analysis of the underlying mechanism and apply the method for monitoring metabolic activity at a single-cell level.

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Language(s): eng - English
 Dates: 2011-10-082011-12-052012-01-172012-03-07
 Publication Status: Published in print
 Pages: 7
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 Table of Contents: -
 Rev. Method: Peer
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Title: Lab on a Chip
  Other : Lab Chip
Source Genre: Journal
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Publ. Info: Cambridge : Royal Society of Chemistry
Pages: - Volume / Issue: 12 (5) Sequence Number: - Start / End Page: 916 - 922 Identifier: Other: 1473-0197
CoNE: /journals/resource/14730197