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  Functional implications of Neandertal introgression in modern humans

Dannemann, M., Prüfer, K., & Kelso, J. (2017). Functional implications of Neandertal introgression in modern humans. Genome Biology, 18: 61. doi:10.1186/s13059-017-1181-7.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002D-084D-C Version Permalink: https://hdl.handle.net/21.11116/0000-0001-3C68-8
Genre: Journal Article

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Dannemann_Functional_GenBio_2017.pdf (Publisher version), 2MB
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This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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 Creators:
Dannemann, Michael1, Author           
Prüfer, Kay2, Author           
Kelso, Janet1, Author           
Affiliations:
1The Minerva Research Group for Bioinformatics, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society, Deutscher Platz 6, 04103 Leipzig, DE, ou_2074303              
2Genomes, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society, Deutscher Platz 6, 04103 Leipzig, DE, ou_2074331              

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Free keywords: Gene expression regulation, Human evolution, Neandertal introgression, Protein sequence variation
 Abstract: Admixture between early modern humans and Neandertals approximately 50,000–60,000 years ago has resulted in 1.5–4% Neandertal ancestry in the genomes of present-day non-Africans. Evidence is accumulating that some of these archaic alleles are advantageous for modern humans, while others are deleterious; however, the major mechanism by which these archaic alleles act has not been fully explored.

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Language(s): eng - English
 Dates: 2017-04-03
 Publication Status: Published online
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1186/s13059-017-1181-7
 Degree: -

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Title: Genome Biology
Source Genre: Journal
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Publ. Info: London : BioMed Central Ltd.
Pages: - Volume / Issue: 18 Sequence Number: 61 Start / End Page: - Identifier: ISSN: 1465-6906
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000224390_1
ISSN: 1474-760X