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  Glucose-modified silicon nanoparticles for cellular imaging

Hsu, C.-W., Septiadi, D., Lai, C.-H., Chen, P., Seeberger, P. H., & De Cola, L. (2017). Glucose-modified silicon nanoparticles for cellular imaging. ChemPlusChem, 82(4), 660-667. doi:10.1002/cplu.201700054.

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 Creators:
Hsu, Chien-Wei, Author
Septiadi, Dedy, Author
Lai, Chian-Hui1, Author              
Chen, Pengkun, Author
Seeberger, Peter H.1, Author              
De Cola, Luisa, Author
Affiliations:
1Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863306              

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Free keywords: bioimaging, carbohydrates, glyco-nanoparticles, luminescence, silicon nanoparticles
 Abstract: Luminescent silicon nanoparticles have recently attracted attention due to their remarkable stability, covalent functionalisation and tunable photoemission properties. Owing to their biocompatibility, low toxicity, and the small particle size that can be achieved by different synthetic approaches, these nanomaterials are candidates as cellular probes in the field of bioimaging, and potentially for in vivo applications. Tailoring the surface of the particles with active biomolecules such as sugar moieties can be an interesting strategy to increase the kinetics of internalisation or to vary the localisation of nanosystems in living cells. In this study, we synthesised and modified ultrasmall silicon nanoparticles with glucose covalently linked on their surface. Moreover, by varying the ratio between the amount of silicon nanoparticles and the saccharide groups, the amount of glucose, as a capping moiety, can be well controlled. FTIR spectroscopy, NMR spectroscopy, zeta potential measurements and anisotropy decay analysis confirmed the covalent binding of glucose to the nanoparticles. The photophysical behaviour of the surface-functionalised silicon quantum dots was not significantly different to that of the unmodified nanoparticles. In vitro studies demonstrated faster internalisation of the glucose-functionalised nanoparticles into HeLa cells. Different localisation and uptake kinetics of the glucose-modified particles compared to the unmodified particles are discussed in order to reveal the role played by the sugar molecules.

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Language(s): eng - English
 Dates: 2017
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: DOI: 10.1002/cplu.201700054
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Title: ChemPlusChem
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 82 (4) Sequence Number: - Start / End Page: 660 - 667 Identifier: ISSN: 2192-6506