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  Higher body mass index is associated with reduced posterior default mode connectivity in older adults

Beyer, F., Kharabian, S., Huntenburg, J. M., Lampe, L., Luck, T., Riedel-Heller, S. G., et al. (2017). Higher body mass index is associated with reduced posterior default mode connectivity in older adults. Human Brain Mapping, 38(7), 3502-3515. doi:10.1002/hbm.23605.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-4571-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-B569-B
Genre: Journal Article

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Beyer_et_al-2017-Human_Brain_Mapping.pdf (Publisher version), 881KB
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 Creators:
Beyer, Frauke1, 2, Author              
Kharabian, Shahrzad1, Author              
Huntenburg, Julia M.3, Author              
Lampe, Leonie1, 4, Author              
Luck, Tobias4, 5, Author
Riedel-Heller, Steffi G.4, 5, Author
Loeffler, Markus4, Author
Schroeter, Matthias L.1, 4, 6, Author              
Stumvoll, Michael2, 7, Author
Villringer, Arno1, 2, 4, Author              
Witte, Veronica1, 2, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
3Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1356546              
4Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
5Institute of Social Medicine, Occupational Health and Public Health (ISAP), University Hospital Leipzig, Germany, ou_persistent22              
6Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
7Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany , ou_persistent22              

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Free keywords: Brain; Neuroimaging; Obesity; Risk factors; Cognition
 Abstract: Obesity is a complex neurobehavioral disorder that has been linked to changes in brain structure and function. However, the impact of obesity on functional connectivity and cognition in aging humans is largely unknown. Therefore, the association of body mass index (BMI), resting-state network connectivity, and cognitive performance in 712 healthy, well-characterized older adults of the Leipzig Research Center for Civilization Diseases (LIFE) cohort (60–80 years old, mean BMI 27.6 kg/m2 ± 4.2 SD, main sample: n = 521, replication sample: n = 191) was determined. Statistical analyses included a multivariate model selection approach followed by univariate analyses to adjust for possible confounders. Results showed that a higher BMI was significantly associated with lower default mode functional connectivity in the posterior cingulate cortex and precuneus. The effect remained stable after controlling for age, sex, head motion, registration quality, cardiovascular, and genetic factors as well as in replication analyses. Lower functional connectivity in BMI-associated areas correlated with worse executive function. In addition, higher BMI correlated with stronger head motion. Using 3T neuroimaging in a large cohort of healthy older adults, independent negative associations of obesity and functional connectivity in the posterior default mode network were observed. In addition, a subtle link between lower resting-state connectivity in BMI-associated regions and cognitive function was found. The findings might indicate that obesity is associated with patterns of decreased default mode connectivity similar to those seen in populations at risk for Alzheimer's disease.

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Language(s): eng - English
 Dates: 2017-03-242017-01-102017-03-272017-04-112017-07
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/hbm.23605
PMID: 28397392
Other: Epub 2017
 Degree: -

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Project name : -
Grant ID : 713‐241202 ; 713‐241202
Funding program : -
Funding organization : LIFE – Leipzig Research Center for Civilization Diseases at the University of Leipzig
Project name : Obesity Mechanisms / SFB 1052
Grant ID : -
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)

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Title: Human Brain Mapping
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 38 (7) Sequence Number: - Start / End Page: 3502 - 3515 Identifier: ISSN: 1065-9471
CoNE: /journals/resource/954925601686