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  Antagonistic Activities of Sox2 and Brachyury Control the Fate Choice of Neuro-Mesodermal Progenitors

Koch, F., Scholze, M., Wittler, L., Schifferl, D., Sudheer, S., Grote, P., et al. (2017). Antagonistic Activities of Sox2 and Brachyury Control the Fate Choice of Neuro-Mesodermal Progenitors. Developmental Cell, 42, 514-526. doi:10.1016/j.devcel.2017.07.021.

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 Urheber:
Koch, Frederic1, Autor           
Scholze, Manuela1, Autor           
Wittler, Lars1, Autor           
Schifferl, Dennis1, Autor           
Sudheer, Smita1, Autor           
Grote, Phillip1, Autor           
Timmermann, Bernd2, Autor           
Macura, Karol1, Autor           
Herrmann, Bernhard G.1, Autor           
Affiliations:
1Dept. of Developmental Genetics (Head: Bernhard G. Herrmann), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433548              
2Sequencing (Head: Bernd Timmermann), Scientific Service (Head: Christoph Krukenkamp), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479670              

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Schlagwörter: NMP; chromatin; lineage choice; mesoderm; mouse; neuro-mesodermal progenitors; neuroectoderm; single-cell analysis; transcriptome; trunk development
 Zusammenfassung: The spinal cord and mesodermal tissues of the trunk such as the vertebral column and skeletal musculature derive from neuro-mesodermal progenitors (NMPs). Sox2, Brachyury (T), and Tbx6 have been correlated with NMP potency and lineage choice; however, their exact role and interaction in these processes have not yet been revealed. Here we present a global analysis of NMPs and their descending lineages performed on purified cells from embryonic day 8.5 wild-type and mutant embryos. We show that T, cooperatively with WNT signaling, controls the progenitor state and the switch toward the mesodermal fate. Sox2 acts antagonistically and promotes neural development. T is also involved in remodeling the chromatin for mesodermal development. Tbx6 reinforces the mesodermal fate choice, represses the progenitor state, and confers paraxial fate commitment. Our findings refine previous models and establish molecular principles underlying mammalian trunk development, comprising NMP maintenance, lineage choice, and mesoderm formation.

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Sprache(n): eng - English
 Datum: 2017-08-172017-09-11
 Publikationsstatus: Erschienen
 Seiten: 13
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 Identifikatoren: DOI: 10.1016/j.devcel.2017.07.021
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Titel: Developmental Cell
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Cambridge, Mass. : Cell Press
Seiten: - Band / Heft: 42 Artikelnummer: - Start- / Endseite: 514 - 526 Identifikator: ISSN: 1534-5807
CoNE: https://pure.mpg.de/cone/journals/resource/111006902714134