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  HPA axis dysregulation in adult adoptees twenty years after severe institutional deprivation in childhood

Kumsta, R., Schlotz, W., Golm, D., Moser, D., Kennedy, M., Knights, N., et al. (2017). HPA axis dysregulation in adult adoptees twenty years after severe institutional deprivation in childhood. Psychoneuroendocrinology, 86, 196-202. doi:10.1016/j.psyneuen.2017.09.021.

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sci-17-sch-04-hpa.pdf (Publisher version), 312KB
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sci-17-sch-04-hpa.pdf
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Copyright Date:
2017
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© 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY licens

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 Creators:
Kumsta, Robert*, Author
Schlotz, Wolff1, Author           
Golm, Dennis, Author
Moser, Dirk, Author
Kennedy, Mark, Author
Knights, Nicky, Author
Kreppner, Jana, Author
Maughan, Barbara, Author
Rutter, Michael, Author
Sonuga-Barke, Edmund, Author
Affiliations:
1Scientific Services, Max Planck Institute for Empirical Aesthetics, Max Planck Society, ou_2421698              

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Free keywords: Institutional deprivation Early trauma Cortisol awakening response Diurnal cortisol slope ERA study
 Abstract: Hypothalamic–pituitary–adrenal (HPA) axis function is disrupted in institutionally-deprived children – reduced morning cortisol, flattened diurnal slope and blunted reactivity persist even after successful adoption into positive family environments. Here we test whether such effects persist into adulthood. Cortisol release across the day (sampled at awakening, 30 and 45min later, and at four points across the day) was investigated in young adult adoptees who had lived in severe deprivation for up to 43 months in early childhood in Ceaușescu’s Romanian orphanages and a comparison group of non-deprived UK adoptees (Total N=57; mean age=24±0.9years). The mediating role of cortisol levels on adult mental health was examined using data from standardized clinical assessments. Cortisol profiles were disrupted in the Romanian adoptees who experienced more than 6 months deprivation marked by a striking absence of the cortisol awakening response (CAR) and a significantly flatter cortisol curve until 1h 15min after awakening. Whereas institutional deprivation was associated with both cortisol secretion and emergence of emotional problems in young adulthood, path analysis revealed no evidence for a mediating role of CAR disruption in the sub-sample studied here. The results are in line with findings of HPA axis hypo-functionality following early adverse experience and provide strong evidence for long-term programming effects of HPA axis function through experience of institutional deprivation.

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Language(s): eng - English
 Dates: 2017-09-282017-12
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.psyneuen.2017.09.021
 Degree: -

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Title: Psychoneuroendocrinology
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 86 Sequence Number: - Start / End Page: 196 - 202 Identifier: ISSN: 0306-4530