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  Segmental duplications and evolutionary acquisition of UV damage response in the SPATA31 gene family of primates and humans

Bekpen, C., Künzel, S., Xie, C., Eaaswarkhanth, M., Lin, Y.-L., Gokcumen, O., et al. (2017). Segmental duplications and evolutionary acquisition of UV damage response in the SPATA31 gene family of primates and humans. BMC Genomics, 18: 222. doi:10.1186/s12864-017-3595-8.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-904C-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-1F5D-2
Genre: Journal Article

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s12864-017-3595-8.pdf (Publisher version), 2MB
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 Creators:
Bekpen, Cemalettin1, Author              
Künzel, Sven1, Author              
Xie, Chen1, Author              
Eaaswarkhanth, Muthukrishnan, Author
Lin, Yen-Lung, Author
Gokcumen, Omer, Author
Akdis, Cezmi A., Author
Tautz, Diethard1, Author              
Affiliations:
1Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              

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Free keywords: Comparative Genomics; Copy number variation; Core duplicons; SPATA31 gene family; Segmental Duplications; UV response
 Abstract: Segmental duplications are an abundant source for novel gene functions and evolutionary adaptations. This mechanism of generating novelty was very active during the evolution of primates particularly in the human lineage. Here, we characterize the evolution and function of the SPATA31 gene family (former designation FAM75A), which was previously shown to be among the gene families with the strongest signal of positive selection in hominoids. The mouse homologue for this gene family is a single copy gene expressed during spermatogenesis.

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Language(s): eng - English
 Dates: 2016-11-082017-02-202017-03-062017-03
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1186/s12864-017-3595-8
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Project name : NewGenes
Grant ID : 322564
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Title: BMC Genomics
Source Genre: Journal
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Publ. Info: BioMed Central
Pages: - Volume / Issue: 18 Sequence Number: 222 Start / End Page: - Identifier: ISSN: 1471-2164
CoNE: /journals/resource/111000136905010