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  The GABA–working memory relationship in Alzheimer’s disease

Mandal, P. K., Kansara, K., & Dabas, A. (2017). The GABA–working memory relationship in Alzheimer’s disease. Journal of Alzheimer's Disease Reports, 1(1), 43-45. doi:10.3233/ADR-170003.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002E-A097-E Version Permalink: https://hdl.handle.net/21.11116/0000-0003-BCDD-1
Genre: Journal Article

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Mandal_Kansara_2017.pdf (Publisher version), 47KB
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 Creators:
Mandal, Pravat K.1, Author
Kansara, Krity1, Author
Dabas, Aroma1, Author           
Affiliations:
1External Organizations, ou_persistent22              

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Free keywords: Alzheimer’s disease; Functional MRI; GABA; MR spectroscopy; Working memory
 Abstract: Alzheimer’s disease (AD) is a highly debilitating neurodegenerative disease with no cure to date. Emerging
evidence indicates aberrations of the primary inhibitory neurotransmitter GABA in the frontal, parietal and temporal cortices,
and hippocampal regions of the AD brains. GABA levels have been reported to predict working memory (WM) load capacity
in the healthy young population. Since working memory is impaired in AD, it opens an active area of research to investigate
the influence of GABA on WM performance in AD. Advancements in neuroimaging techniques and signal processing
tools can aid in neurochemical profiling of GABA in AD as well as facilitate in probing the role of GABA in AD-specific
impairments of working memory.

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Language(s): eng - English
 Dates: 2017-06-102017-07-06
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3233/ADR-170003
PMID: 30480228
PMC: PMC6159718
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Project name : -
Grant ID : BT/PR7361/MED/30/953/2013 ; BT/HRD/01/05/2015
Funding program : -
Funding organization : Department of Biotechnology, Government of India
Project name : -
Grant ID : -
Funding program : TATA Innovation Fellowship
Funding organization : Department of Biotechnology, Government of India

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Title: Journal of Alzheimer's Disease Reports
Source Genre: Journal
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Publ. Info: IOS Press
Pages: - Volume / Issue: 1 (1) Sequence Number: - Start / End Page: 43 - 45 Identifier: ISSN: 2542-4823
CoNE: https://pure.mpg.de/cone/journals/resource/2542-4823