The GABA–working memory relationship in Alzheimer’s disease

Mandal, Pravat K.; Kansara, Krity; Dabas, Aroma

doi:10.3233/ADR-170003

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The GABA–working memory relationship in Alzheimer’s disease

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Mandal, P. K., Kansara, K., & Dabas, A. (2017). The GABA–working memory relationship in Alzheimer’s disease. Journal of Alzheimer's Disease Reports, 1(1), 43-45. doi:10.3233/ADR-170003.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002E-A097-E

Abstract

Alzheimer’s disease (AD) is a highly debilitating neurodegenerative disease with no cure to date. Emerging
evidence indicates aberrations of the primary inhibitory neurotransmitter GABA in the frontal, parietal and temporal cortices,
and hippocampal regions of the AD brains. GABA levels have been reported to predict working memory (WM) load capacity
in the healthy young population. Since working memory is impaired in AD, it opens an active area of research to investigate
the influence of GABA on WM performance in AD. Advancements in neuroimaging techniques and signal processing
tools can aid in neurochemical profiling of GABA in AD as well as facilitate in probing the role of GABA in AD-specific
impairments of working memory.