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  T1ρ-weighted Dynamic Glucose Enhanced MRI

Schuenke, P., Paech, D., Koehler, C., Windschuh, J., Bachert, P., Ladd, M., et al. (2017). T1ρ-weighted Dynamic Glucose Enhanced MRI. In 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017) (pp. 517-517).

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Item Permalink: https://hdl.handle.net/21.11116/0000-0000-C5B2-8 Version Permalink: https://hdl.handle.net/21.11116/0000-0000-F303-A
Genre: Meeting Abstract

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 Creators:
Schuenke, P, Author
Paech, D, Author
Koehler, C, Author
Windschuh, J, Author
Bachert, P, Author
Ladd, M, Author
Schlemmer, H-P, Author
Radbruch, A, Author
Zaiss, M1, 2, Author           
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: Natural D-glucose can serve as a biodegradable contrast agent for the detection of tumors by means of Chemical Exchange Saturation Transfer (CEST) or Chemical Exchange sensitive Spin-Lock (CESL) Dynamic Glucose Enhanced (DGE) MRI. For application of CESL-based DGE-MRI at a 7T whole-body scanner, we implemented an adiabatic CESL sequence and essentially increased the temporal resolution employing a T1ρ-weighted acquisition scheme. Further, we introduced a simple, robust and quantitative DGE contrast. First application of T1ρ-weighted DGE-MRI in a glioblastoma patient provided a substantial contrast between tumor and healthy brain tissue and showed the dynamic glucose enhancement after a glucose bolus injection.

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 Dates: 2017-04-26
 Publication Status: Issued
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 Identifiers: BibTex Citekey: SchuenkePKWBLSRZ2017_2
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Title: 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017)
Place of Event: Honolulu, HI, USA
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Title: 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 0859 Start / End Page: 517 - 517 Identifier: -