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  Simultaneous fMRI with GCaMP6-mediated neuronal and astrocytic calcium signal recording

Wang, M., He, Y., & Yu, X. (2017). Simultaneous fMRI with GCaMP6-mediated neuronal and astrocytic calcium signal recording. In 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017) (pp. 122-122).

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-C5C0-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-F335-2
Genre: Meeting Abstract

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 Creators:
Wang, M1, Author              
He, Y1, 2, 3, Author              
Yu, X2, 3, Author              
Affiliations:
1Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528695              
2Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
3Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Neurovascular coupling is the basis of the BOLD fMRI, however, the mechanisms of the neurovascular coupling remains elusive. By simultaneous cell-type specific Ca2+ recording with BOLD fMRI, it allowed us to study the cellular specific coupling events through the neuron-glia-vessel network. This work showed neuronal Ca2+ and evoked astrocytic Ca2+ signal were positively correlated to the fMRI signal, but an intrinsic astrocytic Ca2+ signal was negatively correlated to the fMRI signal in the cortex. It indicated a novel neuron-glia-vascular coupling event mediated through the intrinsic astrocytic calcium signal (details mechanistic study in another abstract: ID 4475).

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 Dates: 2017-04-24
 Publication Status: Published in print
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 Identifiers: BibTex Citekey: WangHY2017_2
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Title: 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017)
Place of Event: Honolulu, HI, USA
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Title: 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 0111 Start / End Page: 122 - 122 Identifier: -