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  The impact of white matter hyperintensities on brain functional connectivity in amnestic mild cognitive impairment patients

Torso, M., Mastropasqua, C., Giulietti, G., Serra, L., Olivito, G., Tuzzi, E., et al. (2015). The impact of white matter hyperintensities on brain functional connectivity in amnestic mild cognitive impairment patients. Poster presented at 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015), Toronto, Canada.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0000-F22B-F Version Permalink: https://hdl.handle.net/21.11116/0000-0000-F22C-E
Genre: Poster

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http://www.ismrm.org/15/program_files/TueEPS04.htm (Publisher version)
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 Creators:
Torso, M, Author
Mastropasqua, C, Author
Giulietti, G, Author
Serra, L, Author
Olivito, G, Author
Tuzzi, Elisa1, Author           
Spanò, B, Author
Caltagirone, C, Author
Cercignani, M, Author
Bozzali, M, Author
Affiliations:
1Neuroimaging Laboratory, Santa Lucia Foundation, IRCCS, Rome, Italy, ou_persistent22              

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 Abstract: In this study we used resting state f-MRI to investigate the contribution of White Matter Hyperintensities (WMHs) in determining functional connectivity (FC) changes in amnestic Mild Cognitive Impairment patients, the prodromal stage of Alzheimer disease. WMHs volumes were quantified by semiautomatic method on TSE images and used to distinguish patients in two different groups (high WMHs volume –H and low WMHs volume –L). The main finding of the study was that a higher WMHs volume can determine changes in FC and that these alterations are associated with the presence of cognitive deficits in the patients.

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 Dates: 2015-06-02
 Publication Status: Issued
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Title: 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015)
Place of Event: Toronto, Canada
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Title: 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 3951 Start / End Page: - Identifier: -