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Zusammenfassung:
In this study we used resting state f-MRI to investigate the contribution of White Matter Hyperintensities (WMHs) in determining functional connectivity (FC) changes in amnestic Mild Cognitive Impairment patients, the prodromal stage of Alzheimer disease. WMHs volumes were quantified by semiautomatic method on TSE images and used to distinguish patients in two different groups (high WMHs volume –H and low WMHs volume –L). The main finding of the study was that a higher WMHs volume can determine changes in FC and that these alterations are associated with the presence of cognitive deficits in the patients.
