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  Disruption of boundary encoding during sensorimotor sequence learning: An MEG study

Michail, G., Nikulin, V. V., Curio, G., Maess, B., & Ruiz, M. H. (2018). Disruption of boundary encoding during sensorimotor sequence learning: An MEG study. Frontiers in Human Neuroscience, 12: 240. doi:10.3389/fnhum.2018.00240.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-5F22-F Version Permalink: http://hdl.handle.net/21.11116/0000-0003-94D0-A
Genre: Journal Article

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 Creators:
Michail, Georgios1, 2, Author
Nikulin, Vadim V.1, 3, 4, Author              
Curio, Gabriel1, Author
Maess, Burkhard5, Author              
Ruiz, Maria Herrojo1, 6, Author
Affiliations:
1Neurophysics Group, Department of Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              
2Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Centre for Cognition and Decision Making, National Research University Higher School of Economics, Moscow, Russia, ou_persistent22              
5Methods and Development Group MEG and EEG - Cortical Networks and Cognitive Functions, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2205650              
6Department of Psychology, Goldsmiths, University of London, United Kingdom, ou_persistent22              

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Free keywords: Serial order; Boundaries; Prefrontal Cortex; Supplementary motor area; Sensorimotor learning; Sequence learning
 Abstract: Music performance, such as playing the piano or singing, relies on the ability to learn and execute actions and their associated sounds. The process of learning these auditory-motor contingencies depends on the proper encoding of the serial order of the actions and sounds. Among the different serial positions of a behavioral sequence, the first and last (boundary) elements are particularly relevant. Animal and patient studies have demonstrated a specific neural representation for boundary elements in prefrontal cortical regions and in the basal ganglia, highlighting the relevance of their proper encoding. The neural mechanisms underlying the encoding of sequence boundaries in the general human population remain, however, largely unknown. In this study, we examined how alterations of auditory feedback, introduced at different ordinal positions (boundary or within-sequence element), affect the neural and behavioral responses during sensorimotor sequence learning. Analysing the neuromagnetic signals from 20 participants while they performed short piano sequences under the occasional effect of altered feedback, we found that at around 150-200 ms post-keystroke, the neural activities in the dorsolateral prefrontal cortex (DLPFC) and supplementary motor area (SMA) were dissociated for boundary and within-sequence elements. Furthermore, the behavioral data demonstrated that feedback alterations on boundaries led to greater performance costs, such as more errors in the subsequent keystrokes. These findings jointly support the idea that the proper encoding of boundaries is critical in acquiring sensorimotor sequences. They also provide evidence for the involvement of a distinct neural circuitry in humans including prefrontal and higher-order motor areas during the encoding of the different classes of serial order.

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Language(s): eng - English
 Dates: 2018-02-212018-05-242018-06-12
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3389/fnhum.2018.00240
PMID: 29946246
PMC: PMC6005865
Other: eCollection 2018
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Project name : -
Grant ID : HE 6013/1-2
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : -
Grant ID : -
Funding program : Russian Academic Excellence Project 5–100
Funding organization : Ministry of Science and Higher Education of the Russian Federation

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Title: Frontiers in Human Neuroscience
  Abbreviation : Front Hum Neurosci
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 12 Sequence Number: 240 Start / End Page: - Identifier: ISSN: 1662-5161
CoNE: https://pure.mpg.de/cone/journals/resource/1662-5161