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  Synucleins Have Multiple Effects on Presynaptic Architecture

Vargas, K. J., Schrod, N., Davis, T., Fernandez-Busnadiego, R., Taguchi, Y. V., Laugks, U., et al. (2017). Synucleins Have Multiple Effects on Presynaptic Architecture. Cell Reports, 18(1), 161-173. doi:10.1016/j.celrep.2016.12.023.

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PIIS2211124716317132.pdf (Publisher version), 4MB
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 Creators:
Vargas, Karina J.1, Author
Schrod, Nikolas2, Author              
Davis, Taylor1, Author
Fernandez-Busnadiego, Ruben1, Author
Taguchi, Y. V.1, Author
Laugks, Ulrike2, Author              
Lucic, Vladan2, Author              
Chandra, S. S.1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565142              

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Free keywords: presynaptic, endocytosis, synaptic vesicle, tethering, reserve pool, tomography, Parkinson’s disease, amphiphysin, calcineurin, knockout mouse
 Abstract: Synucleins ( a , b , g -synuclein) are abundant presynaptic proteins, with a -synuclein linked to the pathogenesis of Parkinson’s disease. Vargas et al. investigate the effects of deleting synucleins and overexpressing mutated a -synuclein on synapse architecture using electron microscopy. They find that synucleins regulate presynaptic terminal size and synaptic vesicle distribution.

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 Dates: 2017-01-03
 Publication Status: Published online
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 Identifiers: DOI: 10.1016/j.celrep.2016.12.023
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Title: Cell Reports
Source Genre: Journal
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Publ. Info: Maryland Heights, MO : Cell Press
Pages: - Volume / Issue: 18 (1) Sequence Number: - Start / End Page: 161 - 173 Identifier: ISSN: 2211-1247
CoNE: https://pure.mpg.de/cone/journals/resource/2211-1247