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  Fiber optic mediated extracellular glutamate and intracellular calcium recording with simultaneous fMRI

Jiang, Y., Chen, X., & Yu, X. (2018). Fiber optic mediated extracellular glutamate and intracellular calcium recording with simultaneous fMRI. In Joint Annual Meeting ISMRM-ESMRMB 2018.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-7E12-E Version Permalink: http://hdl.handle.net/21.11116/0000-0001-939C-9
Genre: Meeting Abstract

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https://www.ismrm.org/18/ToC.pdf (Abstract)
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 Creators:
Jiang, Y1, 2, Author              
Chen, X1, 2, Author              
Yu, X1, 2, Author              
Affiliations:
1Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528695              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Genetically encoded fluorescent reporter iGluSnFR for extracellular glutamate (Glu) sensing and genetically encoded calcium indicator GCaMP6f for calcium sensing are applied with two channel fiber optic recording system in combination with BOLD fMRI. The intracellular calcium signal from both neurons and astrocytes, as well as the extracellular glutamate signal, were recorded with concurrent BOLD fMRI signal from both hemispheres of anesthetized rats, showing unique temporal dynamic pattern. This multi-modal fMRI platform allows us to specify the neurovascular signaling through the neuro-glial-vascular network and provide better understanding on the cellular and molecular interaction underlying the BOLD fMRI signal.

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 Dates: 2018-06
 Publication Status: Published in print
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 Identifiers: BibTex Citekey: JiangCY2018
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Title: Joint Annual Meeting ISMRM-ESMRMB 2018
Place of Event: Paris, France
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Title: Joint Annual Meeting ISMRM-ESMRMB 2018
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 1008 Start / End Page: - Identifier: -