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Meeting Abstract

Fiber optic mediated extracellular glutamate and intracellular calcium recording with simultaneous fMRI

MPG-Autoren
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Jiang,  Y
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Chen,  X
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Yu,  X
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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https://www.ismrm.org/18/ToC.pdf
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Zitation

Jiang, Y., Chen, X., & Yu, X. (2018). Fiber optic mediated extracellular glutamate and intracellular calcium recording with simultaneous fMRI. In Joint Annual Meeting ISMRM-ESMRMB 2018.


Zitierlink: https://hdl.handle.net/21.11116/0000-0001-7E12-E
Zusammenfassung
Genetically encoded fluorescent reporter iGluSnFR for extracellular glutamate (Glu) sensing and genetically encoded calcium indicator GCaMP6f for calcium sensing are applied with two channel fiber optic recording system in combination with BOLD fMRI. The intracellular calcium signal from both neurons and astrocytes, as well as the extracellular glutamate signal, were recorded with concurrent BOLD fMRI signal from both hemispheres of anesthetized rats, showing unique temporal dynamic pattern. This multi-modal fMRI platform allows us to specify the neurovascular signaling through the neuro-glial-vascular network and provide better understanding on the cellular and molecular interaction underlying the BOLD fMRI signal.