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  Identify the neurovascular coupling efficacy of long-term depolarization or seizer-like events in the hippocampus with optogenetic single-vessel fMRI

Chen, X., Sobczak, F., Chen, Y., & Yu, X. (2018). Identify the neurovascular coupling efficacy of long-term depolarization or seizer-like events in the hippocampus with optogenetic single-vessel fMRI. In Joint Annual Meeting ISMRM-ESMRMB 2018.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-7E29-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-9379-1
Genre: Meeting Abstract

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 Creators:
Chen, X1, 2, Author              
Sobczak, F1, 2, Author              
Chen, Y1, 2, Author              
Yu, X1, 2, Author              
Affiliations:
1Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528695              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Optogenetic activation can elicit seizure-like events in the hippocampus of anesthetized rats. However, it remains unclear how the hemodynamic signaling responds to the seizure-like events or long-term depolarization in hippocampus. Here, we applied the multi-model fMRI platform to acquire concurrent single-vessel fMRI and calcium signal upon optogenetic stimulation in the hippocampus. The neurovascular coupling coefficient was significantly lower for the long-term depolarization/seizure-like calcium event than that of normally evoked events. The reduced neurovascular coupling efficacy during seizure-like events indicates the lack of sufficient blood supply under high-energy demand of long-term depolarization, and eventually causes tissue damage.

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 Dates: 2018-06
 Publication Status: Published in print
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 Identifiers: BibTex Citekey: ChenSCY2018
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Title: Joint Annual Meeting ISMRM-ESMRMB 2018
Place of Event: Paris, France
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Title: Joint Annual Meeting ISMRM-ESMRMB 2018
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 0181 Start / End Page: - Identifier: -