Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  In vivo modulation of endothelial polarization by Apelin receptor signalling

Kwon, H.-B., Wang, S., Helker, C. S., Rasouli, S. J., Maischein, H.-M., Offermanns, S., et al. (2016). In vivo modulation of endothelial polarization by Apelin receptor signalling. NATURE COMMUNICATIONS, 7: 11805. doi:10.1038/ncomms11805.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Kwon, Hyouk-Bum1, Autor           
Wang, ShengPeng2, Autor           
Helker, Christian S.M.1, Autor           
Rasouli, S. Javad1, Autor           
Maischein, Hans-Martin1, Autor           
Offermanns, Stefan2, Autor           
Herzog, Wiebke, Autor
Stainier, Didier Y.R.1, Autor           
Affiliations:
1Developmental Genetics, Max Planck Institute for Heart and Lung Research, Max Planck Society, ou_2591697              
2Pharmacology, Max Planck Institute for Heart and Lung Research, Max Planck Society, ou_2591696              

Inhalt

einblenden:
ausblenden:
Schlagwörter: FLUID SHEAR-STRESS; VASCULAR DEVELOPMENT; CARDIOVASCULAR DEVELOPMENT; MECHANOSENSORY COMPLEX; CELL POLARITY; BLOOD-FLOW; G-PROTEINS; ZEBRAFISH; ATHEROSCLEROSIS; HEARTScience & Technology - Other Topics;
 Zusammenfassung: Endothelial cells (ECs) respond to shear stress by aligning in the direction of flow. However, how ECs respond to flow in complex in vivo environments is less clear. Here we describe an endothelial-specific transgenic zebrafish line, whereby the Golgi apparatus is labelled to allow for in vivo analysis of endothelial polarization. We find that most ECs polarize within 4.5 h after the onset of vigorous blood flow and, by manipulating cardiac function, observe that flow-induced EC polarization is a dynamic and reversible process. Based on its role in EC migration, we analyse the role of Apelin signalling in EC polarization and find that it is critical for this process. Knocking down Apelin receptor function in human primary ECs also affects their polarization. Our study provides new tools to analyse the mechanisms of EC polarization in vivo and reveals an important role in this process for a signalling pathway implicated in cardiovascular disease.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2016
 Publikationsstatus: Online veröffentlicht
 Seiten: 12
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: ISI: 000376972000001
DOI: 10.1038/ncomms11805
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: NATURE COMMUNICATIONS
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND : NATURE PUBLISHING GROUP
Seiten: - Band / Heft: 7 Artikelnummer: 11805 Start- / Endseite: - Identifikator: ISSN: 2041-1723