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  Trade-off of cerebello-cortical and cortico-cortical functional networks for planning in 6-year-old children

Kipping, J. A., Margulies, D. S., Eickhoff, S. B., Lee, A., & Qiu, A. (2018). Trade-off of cerebello-cortical and cortico-cortical functional networks for planning in 6-year-old children. NeuroImage, 176, 510-517. doi:10.1016/j.neuroimage.2018.04.067.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-F6B4-E Version Permalink: http://hdl.handle.net/21.11116/0000-0003-96AB-3
Genre: Journal Article

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 Creators:
Kipping, Judy A.1, Author
Margulies, Daniel S.2, Author              
Eickhoff, Simon B.3, 4, Author
Lee, Annie1, Author
Qiu, Anqi1, 5, 6, Author
Affiliations:
1Department of Biomedical Engineering, National University of Singapore, Singapore, ou_persistent22              
2Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1356546              
3Institute of Systems Neuroscience, University Hospital Düsseldorf, Germany, ou_persistent22              
4Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              
5Singapore Institute for Clinical Sciences, Singapore, ou_persistent22              
6Clinical Imaging Research Center, National University of Singapore, Singapore, ou_persistent22              

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Free keywords: Activation likelihood estimation; Cerebellum; Cerebrum; Resting-state fMRI; Stockings of Cambridge; Tower of London
 Abstract: Childhood is a critical period for the development of cognitive planning. There is a lack of knowledge on its neural mechanisms in children. This study aimed to examine cerebello-cortical and cortico-cortical functional connectivity in association with planning skills in 6-year-olds (n = 76). We identified the cerebello-cortical and cortico-cortical functional networks related to cognitive planning using activation likelihood estimation (ALE) meta-analysis on existing functional imaging studies on spatial planning, and data-driven independent component analysis (ICA) of children's resting-state functional MRI (rs-fMRI). We investigated associations of cerebello-cortical and cortico-cortical functional connectivity with planning ability in 6-year-olds, as assessed using the Stockings of Cambridge task. Long-range functional connectivity of two cerebellar networks (lobules VI and lateral VIIa) with the prefrontal and premotor cortex were greater in children with poorer planning ability. In contrast, cortico-cortical association networks were not associated with the performance of planning in children. These results highlighted the key contribution of the lateral cerebello-frontal functional connectivity, but not cortico-cortical association functional connectivity, for planning ability in 6-year-olds. Our results suggested that brain adaptation to the acquisition of planning ability during childhood is partially achieved through the engagement of the cerebello-cortical functional connectivity.

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Language(s): eng - English
 Dates: 2018-04-092018-02-072018-04-282018-05-032018-08-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2018.04.067
PMID: 29730492
Other: Epub 2018
 Degree: -

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Project name : -
Grant ID : -
Funding program : Translational and Clinical Research (TCR) Flagship Programme
Funding organization : Singapore National Research Foundation
Project name : -
Grant ID : NMRC/TCR/004-NUS/2008 ; NMRC/TCR/012-NUHS/2014 ; NMRC/CBRG/0039/2013
Funding program : -
Funding organization : Singapore Ministry of Health's National Medical Research Council (NMRC)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Singapore Institute for Clinical Sciences, Agency for Science Technology and Research

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 176 Sequence Number: - Start / End Page: 510 - 517 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166