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  Dual time-point [18F]florbetaben PET delivers dual biomarker information in mild cognitive impairment and Alzheimer's disease

Florek, L., Tiepolt, S., Schroeter, M. L., Berrouschot, J., Saur, D., Hesse, S., et al. (2018). Dual time-point [18F]florbetaben PET delivers dual biomarker information in mild cognitive impairment and Alzheimer's disease. Journal of Alzheimer's Disease, 66(3), 1105-1116. doi:10.3233/JAD-180522.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-9E01-B Version Permalink: http://hdl.handle.net/21.11116/0000-0003-9407-E
Genre: Journal Article

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 Creators:
Florek, Lisa1, Author
Tiepolt, Solveig1, Author
Schroeter, Matthias L.2, 3, Author              
Berrouschot, Jörg4, Author
Saur, Dorothee5, Author
Hesse, Swen1, 6, Author
Jochimsen, Thies1, Author
Luthardt, Julia1, Author
Sattler, Bernhard1, Author
Patt, Marianne1, Author
Hoffmann, Karl-Titus7, Author
Villringer, Arno2, 3, 6, Author              
Classen, Joseph5, Author
Gertz, Hermann-Josef8, Author
Sabri, Osama1, Author
Barthel, Henryk1, Author
Affiliations:
1Department of Nuclear Medicine, University of Leipzig, Germany, ou_persistent22              
2Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
4Department of Neurology, Altenburg Hospital, Germany, ou_persistent22              
5Department of Neurology, University Hospital Leipzig, Germany, ou_persistent22              
6Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
7Department of Neuroradiology, University Hospital Leipzig, Germany, ou_persistent22              
8Department of Psychiatry, University of Leipzig, Germany, ou_persistent22              

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Free keywords: Alzheimer’s disease; Dual biomarker; Dual time-point; Dual-phase; Florbetaben; Mild cognitive impairment
 Abstract: BACKGROUND: Current research diagnostic criteria for Alzheimer's disease (AD) and mild cognitive impairment (MCI) due to AD include biomarkers to supplement clinical testing. Recently, we demonstrated that dual time-point [18F]FBB PET is able to deliver both blood flow and amyloid-β (Aβ) load surrogates. OBJECTIVE: The aim of this study was to investigate whether these surrogates can be utilized as AD biomarkers. METHODS: 112 subjects (41 with MCI, 50 with probable/possible AD, 21 with other dementias) underwent dual time-point [18F]FBB PET. Data were visually and relative quantitatively (Herholz scores for the early and composite SUVRs for the late PET data) analyzed. RESULTS: In the early images AD-typical patterns were present in 42% /27% /33% of probable/possible AD/MCI/other dementia cases. In late [18F]FBB PET, 42% /29% /38% of probable/possible AD/ MCI/other dementia cases were Aβ-positive. 17% of the MCIs were categorized as "MCI due to AD-high likelihood", 44% of the probable ADs as "probable AD with high evidence of AD pathophysiological process" and 28% of the possible ADs as "possible AD with evidence of AD pathophysiological process". 27% of all subjects showed a positive diagnostic and progression biomarker. Herholz scores were lower (0.85±0.05 versus 0.88±0.04, p = 0.015) for probable/possible AD versus MCI. Composite late phase SUVRs were significantly higher (1.65±0.23 versus 1.15±0.17, p < 0.005) in Aβ-positive versus Aβ-negative patients. Herholz and MMSE scores were positively correlated (R = 0.30 p = 0.006). CONCLUSION: Dual time-point [18F]FBB PET provides dual biomarker information which enables to categorize MCI and AD dementia patients according to established diagnostic criteria. Thus, dual time-point [18F]FBB PET has great potential to supplement diagnostic dementia workups.

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Language(s): eng - English
 Dates: 2018-09-172018-09-172018-11-232018
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3233/JAD-180522
PMID: 30400095
 Degree: -

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Title: Journal of Alzheimer's Disease
  Abbreviation : J. Alzheimers Dis.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Amsterdam : IOS Press
Pages: - Volume / Issue: 66 (3) Sequence Number: - Start / End Page: 1105 - 1116 Identifier: ISSN: 1387-2877
CoNE: https://pure.mpg.de/cone/journals/resource/1387-2877