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  Structural determinants of reductive terpene cyclization in iridoid biosynthesis

Kries, H., Caputi, L., Stevenson, C. E. M., Kamileen, M. O., Sherden, N. H., Geu-Flores, F., et al. (2016). Structural determinants of reductive terpene cyclization in iridoid biosynthesis. Nature Chemical Biology, 12(1), 6-8. doi:10.1038/nchembio.1955.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0002-B896-5 Version Permalink: https://hdl.handle.net/21.11116/0000-0009-C0AC-C
Genre: Journal Article

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SOC058.pdf (Publisher version), 2MB
 
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685742/ (Publisher version)
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 Creators:
Kries, Hajo1, Author
Caputi, Lorenzo1, Author           
Stevenson, Clare E. M.1, Author
Kamileen, Mohammed O.1, Author
Sherden, Nathaniel H.1, Author
Geu-Flores, Fernando1, Author
Lawson, David M.1, Author
O'Connor, Sarah E.1, Author           
Affiliations:
1external, ou_persistent22              

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Free keywords: PROGESTERONE 5-BETA-REDUCTASE; DIGITALIS-LANATA; STRUCTURE VALIDATION; CARDENOLIDES; REFINEMENT; CHEMISTRY; BIOLOGY; FAMILYBiochemistry & Molecular Biology;
 Abstract: The carbon skeleton of ecologically and pharmacologically important iridoid monoterpenes is formed in a reductive cyclization reaction unrelated to canonical terpene cyclization. Here we report the crystal structure of the recently discovered iridoid cyclase (from Catharanthus roseus) bound to a mechanism-inspired inhibitor that illuminates substrate binding and catalytic function of the enzyme. Key features that distinguish iridoid synthase from its close homolog progesterone 5 beta-reductase are highlighted.

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Language(s): eng - English
 Dates: 2016
 Publication Status: Issued
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: SOC058
DOI: 10.1038/nchembio.1955
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Title: Nature Chemical Biology
  Other : Nat. Chem. Biol.
Source Genre: Journal
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Publ. Info: New York, NY : Nature Pub. Group
Pages: - Volume / Issue: 12 (1) Sequence Number: - Start / End Page: 6 - 8 Identifier: ISSN: 1552-4450
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000021290_1