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  Unlocking the diversity of alkaloids in Catharanthus roseus: nuclear localization suggests metabolic channeling in secondary metabolism

Stavrinides, A., Tatsis, E. C., Foureau, E., Caputi, L., Kellner, F., Courdavault, V., et al. (2015). Unlocking the diversity of alkaloids in Catharanthus roseus: nuclear localization suggests metabolic channeling in secondary metabolism. Chemistry & Biology, 22(3), 336-341. doi:10.1016/j.chembiol.2015.02.006.

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 Creators:
Stavrinides, Anna1, Author
Tatsis, Evangelos C.1, Author
Foureau, Emilien1, Author
Caputi, Lorenzo2, Author              
Kellner, Franziska1, Author
Courdavault, Vincent1, Author
O'Connor, Sarah E.1, Author              
Affiliations:
1external, ou_persistent22              
2External Organizations, ou_persistent22              

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Free keywords: MONOTERPENOID INDOLE ALKALOIDS; CELL-SUSPENSION CULTURES; ALCOHOL-DEHYDROGENASE; BIOMIMETIC SYNTHESIS; STRICTOSIDINE GLUCOSIDASE; HETEROYOHIMBINE ALKALOIDS; OPIUM POPPY; BIOSYNTHESIS; KEY; 4,21-DEHYDROGEISSOSCHIZINEBiochemistry & Molecular Biology;
 Abstract: The extraordinary chemical diversity of the plant-derived monoterpene indole alkaloids, which include vinblastine, quinine, and strychnine, originates from a single biosynthetic intermediate, strictosidine aglycone. Here we report for the first time the cloning of a biosynthetic gene and characterization of the corresponding enzyme that acts at this crucial branchpoint. This enzyme, an alcohol dehydrogenase homolog, converts strictosidine aglycone to the heteroyohimbine-type alkaloid tetrahydroalstonine. We also demonstrate how this enzyme, which uses a highly reactive substrate, may interact with the upstream enzyme of the pathway.

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Language(s): eng - English
 Dates: 2015
 Publication Status: Published in print
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: SOC053
DOI: 10.1016/j.chembiol.2015.02.006
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Title: Chemistry & Biology
  Other : Chem. Biol.
Source Genre: Journal
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Publ. Info: London : Cell Press
Pages: - Volume / Issue: 22 (3) Sequence Number: - Start / End Page: 336 - 341 Identifier: ISSN: 1074-5521
CoNE: https://pure.mpg.de/cone/journals/resource/954925604781