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Free keywords:
THIOESTERASE DOMAIN; POLYKETIDE; SYNTHASEBiochemistry & Molecular Biology;
Abstract:
Enzymatic cyclization of the linear polyketide chain to form a macrolactone is a key step in the biosynthesis of type I polyketide natural products. Structural biology and inhibitor design were used to gain insight into the mechanism and specificity of this enzymatic process.