Cyclization of natural products

O'Connor, Sarah E.

doi:10.1038/nchembio1006-511

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Cyclization of natural products

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O'Connor, S. E. (2006). Cyclization of natural products. Nature Chemical Biology, 2(10), 511-512. doi:10.1038/nchembio1006-511.

Cite as: https://hdl.handle.net/21.11116/0000-0002-A530-D

Abstract

Enzymatic cyclization of the linear polyketide chain to form a macrolactone is a key step in the biosynthesis of type I polyketide natural products. Structural biology and inhibitor design were used to gain insight into the mechanism and specificity of this enzymatic process.