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  Spontaneous eye blink rate and dopamine synthesis capacity: Preliminary evidence for an absence of positive correlation

Sescousse, G., Ligneul, R., van Holst, R. J., Janssen, L., de Boer, F., Janssen, M., et al. (2018). Spontaneous eye blink rate and dopamine synthesis capacity: Preliminary evidence for an absence of positive correlation. European Journal of Neuroscience, 47(9), 1081-1086. doi:10.1111/ejn.13895.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-B4A8-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-9E12-7
Genre: Journal Article

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 Creators:
Sescousse, Guillaume1, Author
Ligneul, Romain 1, Author
van Holst, Ruth J. 1, 2, Author
Janssen, Lieneke1, 3, Author              
de Boer , Femke 1, 4, Author
Janssen, Marcel 5, Author
Berry , Anne S. 6, Author
Jagust, William J. 6, Author
Cools, Roshan 1, 2, Author
Affiliations:
1Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
2Academic Medical Center (AMC), University of Amsterdam, the Netherlands, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Social, Health, and Organizational Psychology, Utrecht University, the Netherlands, ou_persistent22              
5Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands, ou_persistent22              
6Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA, ou_persistent22              

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Free keywords: PET; [18F]DOPA; Dopamine; Eye blink rate; Proxy measure
 Abstract: Dopamine is central to a number of cognitive functions and brain disorders. Given the cost of neurochemical imaging in humans, behavioural proxy measures of dopamine have gained in popularity in the past decade, such as spontaneous eye blink rate (sEBR). Increased sEBR is commonly associated with increased dopamine function based on pharmacological evidence and patient studies. Yet, this hypothesis has not been validated using in vivo measures of dopamine function in humans. To fill this gap, we measured sEBR and striatal dopamine synthesis capacity using [18F]DOPA PET in 20 participants (nine healthy individuals and 11 pathological gamblers). Our results, based on frequentist and Bayesian statistics, as well as region‐of‐interest and voxel‐wise analyses, argue against a positive relationship between sEBR and striatal dopamine synthesis capacity. They show that, if anything, the evidence is in favour of a negative relationship. These results, which complement findings from a recent study that failed to observe a relationship between sEBR and dopamine D2 receptor availability, suggest that caution and nuance are warranted when interpreting sEBR in terms of a proxy measure of striatal dopamine.

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Language(s): eng - English
 Dates: 2018-02-172017-11-252018-02-272018-03-072018-05-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1111/ejn.13895
PMID: 29514419
PMC: PMC5969266
Other: Epub 2018
 Degree: -

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Project name : -
Grant ID : 446.11.025
Funding program : Rubicon grant
Funding organization : Netherlands Organisation for Scientific Research (NWO)
Project name : -
Grant ID : 016.155.218
Funding program : Veni-Grant
Funding organization : Netherlands Organisation for Scientific Research (NWO)
Project name : -
Grant ID : 2015/24762
Funding program : Vici-Grant
Funding organization : Netherlands Organisation for Scientific Research (NWO)
Project name : -
Grant ID : -
Funding program : James McDonnell scholar award
Funding organization : James S. McDonnell Foundation

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Title: European Journal of Neuroscience
  Other : Eur. J. Neurosci
Source Genre: Journal
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Publ. Info: Oxford, UK : Published on behalf of the European Neuroscience Association by Oxford University Press
Pages: - Volume / Issue: 47 (9) Sequence Number: - Start / End Page: 1081 - 1086 Identifier: ISSN: 0953-816X
CoNE: https://pure.mpg.de/cone/journals/resource/954925575988