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  Progressive ventricles enlargement and cerebrospinal fluid volume increases as a marker of neurodegeneration in patients with spinal cord injury: A longitudinal magnetic resonance imaging study

Seif, M., Ziegler, G., & Freund, P. (2018). Progressive ventricles enlargement and cerebrospinal fluid volume increases as a marker of neurodegeneration in patients with spinal cord injury: A longitudinal magnetic resonance imaging study. Journal of Neurotrauma, 35(24), 2941-2946. doi:10.1089/neu.2017.5522.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-B8CB-A Version Permalink: http://hdl.handle.net/21.11116/0000-0003-9C4B-A
Genre: Journal Article

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 Creators:
Seif, Maryam1, 2, Author
Ziegler, Gabriel3, 4, Author
Freund, Patrick1, 2, 5, Author              
Affiliations:
1Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
2Spinal Cord Injury Center, University of Zurich, Switzerland, ou_persistent22              
3Dementia Research, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
4German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany, ou_persistent22              
5Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              

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Free keywords: brain volume; CSF volume; spinal cord injury; VBM; ventricle enlargement
 Abstract: Next to gray and white matter atrophy, cerebrospinal fluid (CSF) volume and ventricular dilation may be surrogate biomarkers for brain atrophy in spinal cord injury (SCI). We therefore aimed to track brain atrophy by means of CSF volume changes and ventricular enlargements over two years after SCI. Fifteen patients with SCI and 18 healthy controls underwent a series of T1-weighted scans during five time points over two years. Changes of CSF/intracranial volume (CSF/ICV) ratio, CSF volume, and ventricular enlargement rate over time were determined. Sample sizes with 80% power and 5% significance were calculated to detect a range of treatment effects for a two-armed trial. There was a significant cross-sectional increased CSF/ICV ratio in patients compared with controls at each time point (p < 0.02). The rate of CSF/ICV changes, however, was not significantly different between groups over time. CSF volume increased linearly over bilateral sensorimotor cortices (left: p = 0.002, right: p = 0.042) and in the supracerebellar space (p < 0.001) within two years. An acceleration of the enlargement within the third (p = 0.017) and the fourth (p = 0.006) ventricles was observed in patients over time. Sample size estimation for six-month trials with CSF volume requires 25 patients per treatment arm to detect a hypothetical treatment effect in terms of slowing of atrophy rate of 30%. This study shows that SCI-induced changes in CSF/ICV ratio and ventricular expansion rate provide additional information on the neurodegenerative processes after injury. The sensitivity to scoring treatment effects speaks to its potential to serve as a sensitive biomarker in addition to local atrophy measures.

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Language(s): eng - English
 Dates: 2018-09-042018-12-13
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1089/neu.2017.5522
PMID: 29993326
PMC: PMC6306675
Other: Epub 2018
 Degree: -

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Project name : Antibodies against Nogo-A to enhance plasticity, regeneration and functional recovery after acute spinal cord injury, a multicenter European clinical proof of concept trial / NISCI
Grant ID : 681094
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : -
Grant ID : 15.0137
Funding program : -
Funding organization : Swiss State Secretariat for Education, Research and Innovation (SERI)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Wings for Life, Austria

Source 1

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Title: Journal of Neurotrauma
  Other : J. Neurotrauma
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : M.A. Liebert
Pages: - Volume / Issue: 35 (24) Sequence Number: - Start / End Page: 2941 - 2946 Identifier: ISSN: 0897-7151
CoNE: https://pure.mpg.de/cone/journals/resource/954925561573