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  Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery

Albrechtsen, N. J. W., Geyer, P. E., Doll, S., Treit, P. V., Bojsen-Moller, K. N., Martinussen, C., et al. (2018). Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery. Cell Systems, 7(6), 601-612.e3. doi:10.1016/j.cels.2018.10.012.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0002-D3AE-C Version Permalink: https://hdl.handle.net/21.11116/0000-0002-D3AF-B
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 Creators:
Albrechtsen, Nicolai J. Wewer1, Author           
Geyer, Philipp E.1, Author           
Doll, Sophia1, Author           
Treit, Peter V.1, Author           
Bojsen-Moller, Kirstine N.2, Author
Martinussen, Christoffer2, Author
Jorgensen, Nils B.2, Author
Torekov, Signe S.2, Author
Meier, Florian1, Author           
Niu, Lili2, Author
Santos, Alberto2, Author
Keilhauer, Eva C.1, Author           
Holst, Jens J.2, Author
Madsbad, Sten2, Author
Mann, Matthias1, Author           
Affiliations:
1Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              
2external, ou_persistent22              

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Free keywords: INSULIN SENSITIVITY; SECRETION; DISEASE; OBESITY; WEIGHT; HEALTH; METABOLISM; RESISTANCE; GLP-1; HDLBiochemistry & Molecular Biology; Cell Biology;
 Abstract: Obesity-related diseases affect half of the global population, and bariatric surgery is one of the few interventions with long-lasting weight loss and cardio-metabolic effects. Here, we investigated the effect of Roux-en-Y gastric bypass surgery on the plasma proteome, hypothesizing that specific proteins or protein patterns may serve as key mediators and markers of the metabolic response. We performed mass spectrometry (MS)-based proteomics on two longitudinal studies encompassing 47 morbidly obese patients, generating quantitative information on more than 1,700 proteins. A global correlation matrix incorporating about 200,000 relationships revealed functional connections between proteins and assigned them to physiological processes. The main classes of significantly altered proteins were markers of systemic inflammation and those involved in lipid metabolism. Our data highlight robust correlative and anti-correlative behaviors of circulating proteins to each other and to clinical parameters. A group of inflammation-related proteins showed distinct inverse relationships to proteins consistently associated with insulin sensitivity.

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Language(s): eng - English
 Dates: 2018
 Publication Status: Issued
 Pages: 15
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000454344300005
DOI: 10.1016/j.cels.2018.10.012
 Degree: -

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Project name : MSmed project
Grant ID : 686547
Funding program : Horizon 2020 (H2020)
Funding organization : European Commission (EC)
Project name : GA ERC-2012-SyG_318987; ToPAG project
Grant ID : 318987
Funding program : Funding Programme 7 (FP7)
Funding organization : European Commission (EC)

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Title: Cell Systems
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Elsevier
Pages: - Volume / Issue: 7 (6) Sequence Number: - Start / End Page: 601 - 612.e3 Identifier: ISSN: 2405-4712