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  Effects of aging on T1, T2*, and QSM MRI values in the subcortex

Keuken, M. C., Bazin, P.-L., Backhouse, K., Beekhuizen, S., Himmer, L., Kandola, A., et al. (2017). Effects of aging on T1, T2*, and QSM MRI values in the subcortex. Brain Structure & Function, 222(6), 2487-2505. doi:10.1007/s00429-016-1352-4.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-E131-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-B627-4
Genre: Journal Article

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 Creators:
Keuken, M. C. 1, Author
Bazin, Pierre-Louis2, Author              
Backhouse, K.1, Author
Beekhuizen, S.1, Author
Himmer, L.1, Author
Kandola, A.1, Author
Lafeber, J. J. 1, Author
Prochazkova, L.1, Author
Trutti, A.1, Author
Schäfer, A.1, Author
Turner, Robert1, 3, Author              
Forstmann, B. U. 1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
3Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              

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Free keywords: Ultra-high field 7 T MRI; T1 T∗2; QSM; Subcortex; Basal ganglia; Aging
 Abstract: The aging brain undergoes several anatomical changes that can be measured with Magnetic Resonance Imaging (MRI). Early studies using lower field strengths have assessed changes in tissue properties mainly qualitatively, using T1- or T∗2- weighted images to provide image contrast. With the development of higher field strengths (7 T and above) and more advanced MRI contrasts, quantitative measures can be acquired even of small subcortical structures. This study investigates volumetric, spatial, and quantitative MRI parameter changes associated with healthy aging in a range of subcortical nuclei, including the basal ganglia, red nucleus, and the periaqueductal grey. The results show that aging has a heterogenous effects across regions. Across the subcortical areas an increase of T1 values is observed, most likely indicating a loss of myelin. Only for a number of areas, a decrease of T∗2 and increase of QSM is found, indicating an increase of iron. Aging also results in a location shift for a number of structures indicating the need for visualization of the anatomy of individual brains.

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Language(s): eng - English
 Dates: 2016-07-192016-12-162017-02-062017-08
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1007/s00429-016-1352-4
PMC: PMC5541117
PMID: 28168364
Other: Epub 2017
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Project name : -
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Funding program : Vidi grant
Funding organization : Netherlands Organisation for Scientific Research (NWO)
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Grant ID : -
Funding program : Starter Grant
Funding organization : European Commission (EC)

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Title: Brain Structure & Function
  Abbreviation : Brain Struct Funct
Source Genre: Journal
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Publ. Info: Berlin : Springer
Pages: - Volume / Issue: 222 (6) Sequence Number: - Start / End Page: 2487 - 2505 Identifier: ISSN: 1863-2653
CoNE: https://pure.mpg.de/cone/journals/resource/1863-2653