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  Cognitive performance in healthy older adults relates to spontaneous switching between states of functional connectivity during rest

Cabral, J., Vidaurre, D., Marques, P., Magalhães, R., Moreira, P. S., Soares, J. M., et al. (2017). Cognitive performance in healthy older adults relates to spontaneous switching between states of functional connectivity during rest. Scientific Reports, 7(1): 5135. doi:10.1038/s41598-017-05425-7.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0002-E2E7-A Version Permalink: https://hdl.handle.net/21.11116/0000-0003-C02C-3
Genre: Journal Article

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 Creators:
Cabral, Joana1, Author
Vidaurre, Diego1, Author
Marques, Paulo 1, Author
Magalhães, Ricardo 1, Author
Moreira, Pedro Silva 1, Author
Soares, José Miguel 1, Author
Deco, Gustavo1, 2, Author           
Sousa, Nuno 1, Author
Kringelbach , Morten L.1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              

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Free keywords: Cognitive ageing; Data mining; Dynamical systems
 Abstract: Growing evidence has shown that brain activity at rest slowly wanders through a repertoire of different states, where whole-brain functional connectivity (FC) temporarily settles into distinct FC patterns. Nevertheless, the functional role of resting-state activity remains unclear. Here, we investigate how the switching behavior of resting-state FC relates with cognitive performance in healthy older adults. We analyse resting-state fMRI data from 98 healthy adults previously categorized as being among the best or among the worst performers in a cohort study of >1000 subjects aged 50+ who underwent neuropsychological assessment. We use a novel approach focusing on the dominant FC pattern captured by the leading eigenvector of dynamic FC matrices. Recurrent FC patterns – or states – are detected and characterized in terms of lifetime, probability of occurrence and switching profiles. We find that poorer cognitive performance is associated with weaker FC temporal similarity together with altered switching between FC states. These results provide new evidence linking the switching dynamics of FC during rest with cognitive performance in later life, reinforcing the functional role of resting-state activity for effective cognitive processing.

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Language(s): eng - English
 Dates: 2016-12-192017-05-302017-07-11
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41598-017-05425-7
PMC: PMC5506029
PMID: 28698644
 Degree: -

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Project name : The plasticity of parental caregiving: characterizing the brain mechanisms underlying normal and disrupted development of parenting / CAREGIVING
Grant ID : 615539
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : -
Grant ID : DNRF117
Funding program : -
Funding organization : Danish National Research Foundation
Project name : -
Grant ID : 098369/Z/12/Z
Funding program : Wellcome Trust Strategic Award
Funding organization : Wellcome Trust
Project name : Better mental health during ageing based on temporal prediction of individual brain ageing trajectories / TEMPO
Grant ID : P-139977
Funding program : -
Funding organization : Fundação Calouste Gulbenkian (Portugal)
Project name : -
Grant ID : PDE/BDE/113604/2015 ; PDE/BDE/113601/2015
Funding program : PhD-iHES program
Funding organization : Fundação para a Ciência e a Tecnologia
Project name : The Dynamical and Structural Basis of Human Mind Complexity: Segregation and Integration of Information and Processing in the Brain / DYSTRUCTURE
Grant ID : 295129
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : Spanish National Project Complexity of Brain States
Grant ID : PSI2016-75688-P
Funding program : -
Funding organization : Spanish Research Agency (AEI) and the European Regional Development Fund (ERDF)
Project name : Human Brain Project Specific Grant Agreement 1 / HBP SGA1
Grant ID : 720270
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : -
Grant ID : -
Funding program : Portuguese North Regional Operational Program (ON.2)
Funding organization : National Strategic Reference Framework (QREN)
Project name : -
Grant ID : -
Funding program : European Regional Development Fund
Funding organization : European Commission (EC)
Project name : -
Grant ID : PEst-C/SAU/LA0026-/2013
Funding program : Projecto Estratégico
Funding organization : Fundação para a Ciência e a Tecnologia
Project name : -
Grant ID : COMP-01-0124-FEDER-037298
Funding program : European Regional Development Fund COMPETE
Funding organization : European Commission (EC)
Project name : -
Grant ID : NORTE-01-0145-FEDER-000013
Funding program : Northern Portugal Regional Operational Programme (NORTE 2020)
Funding organization : European Commission (EC)

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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 7 (1) Sequence Number: 5135 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322