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  Cognitive performance in healthy older adults relates to spontaneous switching between states of functional connectivity during rest

Cabral, J., Vidaurre, D., Marques, P., Magalhães, R., Moreira, P. S., Soares, J. M., Deco, G., Sousa, N., & Kringelbach, M. L. (2017). Cognitive performance in healthy older adults relates to spontaneous switching between states of functional connectivity during rest. Scientific Reports, 7(1):. doi:10.1038/s41598-017-05425-7.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-0002-E2E7-A 版のパーマリンク: https://hdl.handle.net/21.11116/0000-0003-C02C-3
資料種別: 学術論文

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Cabral_2017.pdf (出版社版), 6MB
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https://hdl.handle.net/21.11116/0000-0002-E2E9-8
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Cabral_2017.pdf
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application/pdf / [MD5]
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作成者

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 作成者:
Cabral, Joana1, 著者
Vidaurre, Diego1, 著者
Marques, Paulo 1, 著者
Magalhães, Ricardo 1, 著者
Moreira, Pedro Silva 1, 著者
Soares, José Miguel 1, 著者
Deco, Gustavo1, 2, 著者           
Sousa, Nuno 1, 著者
Kringelbach , Morten L.1, 著者
所属:
1External Organizations, ou_persistent22              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              

内容説明

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キーワード: Cognitive ageing; Data mining; Dynamical systems
 要旨: Growing evidence has shown that brain activity at rest slowly wanders through a repertoire of different states, where whole-brain functional connectivity (FC) temporarily settles into distinct FC patterns. Nevertheless, the functional role of resting-state activity remains unclear. Here, we investigate how the switching behavior of resting-state FC relates with cognitive performance in healthy older adults. We analyse resting-state fMRI data from 98 healthy adults previously categorized as being among the best or among the worst performers in a cohort study of >1000 subjects aged 50+ who underwent neuropsychological assessment. We use a novel approach focusing on the dominant FC pattern captured by the leading eigenvector of dynamic FC matrices. Recurrent FC patterns – or states – are detected and characterized in terms of lifetime, probability of occurrence and switching profiles. We find that poorer cognitive performance is associated with weaker FC temporal similarity together with altered switching between FC states. These results provide new evidence linking the switching dynamics of FC during rest with cognitive performance in later life, reinforcing the functional role of resting-state activity for effective cognitive processing.

資料詳細

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言語: eng - English
 日付: 2016-12-192017-05-302017-07-11
 出版の状態: オンラインで出版済み
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子（DOI, ISBNなど）: DOI: 10.1038/s41598-017-05425-7
PMC: PMC5506029
PMID: 28698644
 学位: -

関連イベント

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訴訟

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Project information

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Project name : The plasticity of parental caregiving: characterizing the brain mechanisms underlying normal and disrupted development of parenting / CAREGIVING
Grant ID : 615539
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : -
Grant ID : DNRF117
Funding program : -
Funding organization : Danish National Research Foundation
Project name : -
Grant ID : 098369/Z/12/Z
Funding program : Wellcome Trust Strategic Award
Funding organization : Wellcome Trust
Project name : Better mental health during ageing based on temporal prediction of individual brain ageing trajectories / TEMPO
Grant ID : P-139977
Funding program : -
Funding organization : Fundação Calouste Gulbenkian (Portugal)
Project name : -
Grant ID : PDE/BDE/113604/2015 ; PDE/BDE/113601/2015
Funding program : PhD-iHES program
Funding organization : Fundação para a Ciência e a Tecnologia
Project name : The Dynamical and Structural Basis of Human Mind Complexity: Segregation and Integration of Information and Processing in the Brain / DYSTRUCTURE
Grant ID : 295129
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : Spanish National Project Complexity of Brain States
Grant ID : PSI2016-75688-P
Funding program : -
Funding organization : Spanish Research Agency (AEI) and the European Regional Development Fund (ERDF)
Project name : Human Brain Project Specific Grant Agreement 1 / HBP SGA1
Grant ID : 720270
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : -
Grant ID : -
Funding program : Portuguese North Regional Operational Program (ON.2)
Funding organization : National Strategic Reference Framework (QREN)
Project name : -
Grant ID : -
Funding program : European Regional Development Fund
Funding organization : European Commission (EC)
Project name : -
Grant ID : PEst-C/SAU/LA0026-/2013
Funding program : Projecto Estratégico
Funding organization : Fundação para a Ciência e a Tecnologia
Project name : -
Grant ID : COMP-01-0124-FEDER-037298
Funding program : European Regional Development Fund COMPETE
Funding organization : European Commission (EC)
Project name : -
Grant ID : NORTE-01-0145-FEDER-000013
Funding program : Northern Portugal Regional Operational Programme (NORTE 2020)
Funding organization : European Commission (EC)

出版物 1

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出版物名: Scientific Reports
  省略形 : Sci. Rep.
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: London, UK : Nature Publishing Group
ページ: - 巻号: 7 (1) 通巻号: 5135 開始・終了ページ: - 識別子（ISBN, ISSN, DOIなど）: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322