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  The companion of cellulose synthase 1 confers salt tolerance through a Tau-like mechanism in plants

Kesten, C., Wallmann, A., Schneider, R., McFarlane, H. E., Diehl, A., Khan, G. A., et al. (2019). The companion of cellulose synthase 1 confers salt tolerance through a Tau-like mechanism in plants. Nature Communications, 10(1): 857. doi:10.1038/s41467-019-08780-3.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-0EF4-B Version Permalink: http://hdl.handle.net/21.11116/0000-0004-4FF5-0
Genre: Journal Article

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 Creators:
Kesten, C.1, Author              
Wallmann, Arndt2, Author
Schneider, R.1, Author              
McFarlane, Heather E.2, Author
Diehl, Anne2, Author
Khan, Ghazanfar Abbas2, Author
van Rossum, Barth-Jan2, Author
Lampugnani, Edwin R.2, Author
Szymanski, Witold G.1, Author              
Cremer, Nils2, Author
Schmieder, Peter2, Author
Ford, Kristina L.2, Author
Seiter, Florian2, Author
Heazlewood, Joshua L.2, Author
Sanchez-Rodriguez, Clara2, Author
Oschkinat, Hartmut2, Author
Persson, S.1, Author              
Affiliations:
1Plant Cell Walls - Persson, Max Planck Research Groups, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753318              
2external, ou_persistent22              

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 Abstract: Microtubules are filamentous structures necessary for cell division, motility and morphology, with dynamics critically regulated by microtubule-associated proteins (MAPs). Here we outline the molecular mechanism by which the MAP, COMPANION OF CELLULOSE SYNTHASE1 (CC1), controls microtubule bundling and dynamics to sustain plant growth under salt stress. CC1 contains an intrinsically disordered N-terminus that links microtubules at evenly distributed points through four conserved hydrophobic regions. By NMR and live cell analyses we reveal that two neighboring residues in the first hydrophobic binding motif are crucial for the microtubule interaction. The microtubule-binding mechanism of CC1 is reminiscent to that of the prominent neuropathology-related protein Tau, indicating evolutionary convergence of MAP functions across animal and plant cells.

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Language(s): eng - English
 Dates: 2019
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1038/s41467-019-08780-3
Other: Kesten2019
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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: 857 Volume / Issue: 10 (1) Sequence Number: 857 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723