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Abstract:
Purpose: To investigate the localization dependence of relaxationcompensated
multi-pool Chemical-Exchange-Saturation-Transfer (CEST) MRI
at 7T and histopathological parameters in newly diagnosed untreated WHO IV°
glioma patients.
Methods and Materials: Twenty patients with newly diagnosed WHO IV°
gliomas were prospectively included in this study and investigated at a 7T
whole-body scanner (Siemens Healthcare, Erlangen, Germany). Mean CEST
signal intensities (Nuclear-Overhauser-Effect(NOE), Amide-Proton-
Transfer(APT), Downfield_NOE-suppressed APT(DNS_APT)), ADC
parameters and histopathological parameters of the tumor volumes were
evaluated with regard to extension, localization (brain hemisphere and lobe)
and contact to the subventricular zone using non-parametric Mann-Whitney
tests, ANOVA on ranks test and Spearman correlation.
Results: Mean CEST APT&DNS_APT signal intensities (0,156±0,118 &
0,137±0,116) were significantly increased in right vs. left hemisphere
glioblastomas (0,072±0,014 & 0,048±0,014), (p=0,044 and 0,010). Mean ADC
parameter were significantly decreased in right vs. left hemisphere
glioblastomas (1,04*10^7±0,08*10^7 vs. 1,18*10^7±0,12*10^7) (p=0,046).
Mean CEST NOE signal intensity didn’t differ significantly between both
hemispheres, but was significantly increased in case of subventricular zone
contact (0,101±0,015 vs. 0,118±0,015) (p=0,037). The lobe localization and
extension of the tumor had no significant effect on CEST and ADC signals.
CEST APT&DNS_APT and ADC signal intensities did significantly correlate (-
0,67 and -0,56) (p<0,01), but not CEST NOE and ADC parameters.
Histopathological parameters were not significantly different with regard to
different localizations.
Conclusion: Relaxation-compensated multi-pool CEST MRI signal depends
on the anatomic localization. Amide CEST and ADC are positively correlating -
NOE parameters are solemly different with regard to subventricular zone
contact, possibly showing complementary information to Amide CEST and
ADC.
