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Relaxation-compensated multi-pool CEST signal at 7T MRI of glioblastomas is dependent on the anatomic localisation

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Zaiss,  M
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Dreher, C., Windschuh, J., Sahm, F., Bachert, P., Ladd, M., Zaiss, M., et al. (2018). Relaxation-compensated multi-pool CEST signal at 7T MRI of glioblastomas is dependent on the anatomic localisation. Insights into Imaging, 9(Supplement 1): B-0933, S381.


Cite as: http://hdl.handle.net/21.11116/0000-0003-23A8-8
Abstract
Purpose: To investigate the localization dependence of relaxationcompensated multi-pool Chemical-Exchange-Saturation-Transfer (CEST) MRI at 7T and histopathological parameters in newly diagnosed untreated WHO IV° glioma patients. Methods and Materials: Twenty patients with newly diagnosed WHO IV° gliomas were prospectively included in this study and investigated at a 7T whole-body scanner (Siemens Healthcare, Erlangen, Germany). Mean CEST signal intensities (Nuclear-Overhauser-Effect(NOE), Amide-Proton- Transfer(APT), Downfield_NOE-suppressed APT(DNS_APT)), ADC parameters and histopathological parameters of the tumor volumes were evaluated with regard to extension, localization (brain hemisphere and lobe) and contact to the subventricular zone using non-parametric Mann-Whitney tests, ANOVA on ranks test and Spearman correlation. Results: Mean CEST APT&DNS_APT signal intensities (0,156±0,118 & 0,137±0,116) were significantly increased in right vs. left hemisphere glioblastomas (0,072±0,014 & 0,048±0,014), (p=0,044 and 0,010). Mean ADC parameter were significantly decreased in right vs. left hemisphere glioblastomas (1,04*10^7±0,08*10^7 vs. 1,18*10^7±0,12*10^7) (p=0,046). Mean CEST NOE signal intensity didn’t differ significantly between both hemispheres, but was significantly increased in case of subventricular zone contact (0,101±0,015 vs. 0,118±0,015) (p=0,037). The lobe localization and extension of the tumor had no significant effect on CEST and ADC signals. CEST APT&DNS_APT and ADC signal intensities did significantly correlate (- 0,67 and -0,56) (p<0,01), but not CEST NOE and ADC parameters. Histopathological parameters were not significantly different with regard to different localizations. Conclusion: Relaxation-compensated multi-pool CEST MRI signal depends on the anatomic localization. Amide CEST and ADC are positively correlating - NOE parameters are solemly different with regard to subventricular zone contact, possibly showing complementary information to Amide CEST and ADC.