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  Reinforced Ni(II)-cyclam derivatives as dual 1H/19F MRI probes

Pujales-Paradela, R., Savić, T., Brandariz, I., Pérez-Lourido, P., Angelovski, G., Esteban-Gómez, D., et al. (2019). Reinforced Ni(II)-cyclam derivatives as dual 1H/19F MRI probes. Chemical Communications, 55(28), 4115-4118. doi:10.1039/c9cc01204d.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-351C-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-5D2C-5
Genre: Journal Article

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 Creators:
Pujales-Paradela, R, Author
Savić, T1, 2, Author              
Brandariz, I, Author
Pérez-Lourido, P, Author
Angelovski, G1, 2, Author              
Esteban-Gómez, D, Author
Platas-Iglesias, C, Author
Affiliations:
1Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528691              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Reinforced cross-bridged Ni2+-cyclam complexes were functionalised with pendant arms containing both amide protons and CF3 groups that lead to a dual 1H/19F response. The resulting complexes possess very high inertness favourable for MRI applications. The paramagnetism of the Ni2+ ion shifts the amide resonance 56 ppm away from bulk water favouring the chemical exchange saturation transfer (CEST) effect and shortening the acquisition times in 19F magnetic resonance imaging (MRI) experiments, thus enhancing the signal-to-noise ratios compared to the fluorinated diamagnetic reference.

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 Dates: 2019-032019-04
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1039/c9cc01204d
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Title: Chemical Communications
  Other : Chem. Commun.
Source Genre: Journal
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Publ. Info: Cambridge, UK : Royal Society of Chemistry
Pages: - Volume / Issue: 55 (28) Sequence Number: - Start / End Page: 4115 - 4118 Identifier: ISSN: 1359-7345
CoNE: https://pure.mpg.de/cone/journals/resource/954928495413