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  Effects of omega-3 fatty acids on resting cerebral perfusion in patients with mild cognitive impairment: A randomized controlled trial

Schwarz, C., Wirth, M., Gerischer, L., Grittner, U., Witte, A. V., Köbe, T., et al. (2018). Effects of omega-3 fatty acids on resting cerebral perfusion in patients with mild cognitive impairment: A randomized controlled trial. The Journal of Prevention of Alzheimer's Disease: JPAD, 5(1), 26-30. doi:10.14283/jpad.2017.23.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0003-47BB-B Version Permalink: https://hdl.handle.net/21.11116/0000-0004-3A97-1
Genre: Journal Article

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 Creators:
Schwarz, Claudia1, Author
Wirth, M.1, Author
Gerischer, L.1, Author
Grittner, U. 1, Author
Witte, A. Veronica1, 2, Author           
Köbe, T.1, Author
Flöel, A.1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: Omega-3 fatty acids; cerebral perfusion; mild cognitive impairment; Alzheimer’s disease prevention; dynamic susceptibility contrast magnetic resonance imaging
 Abstract: Alteration of cerebral perfusion can be considered as a possible therapeutic target in mild cognitive impairment. This randomized, placebo-controlled, double-blind proof-of-concept study assessed effects of omega-3 fatty acids on cerebral perfusion in patients with mild cognitive impairment. In thirteen patients (omega:n=5; placebo:n=8) cerebral perfusion was measured before and after 26-weeks intervention within posterior cortical regions using magnetic resonance imaging. There was a medium effect of intervention on cerebral blood flow (η2=0.122) and blood volume (η2=0.098). The omega group showed an increase in blood flow (mean difference: 0.02 [corresponds to 26.1%], 95% confidence interval:0.00-0.05) and blood volume (mean difference: 0.08 [corresponds to 18.5%], 95% confidence interval:0.01-0.15), which was not observed in the placebo group. These preliminary findings suggest that omega-3 fatty acids supplementation may improve perfusion in cerebral regions typically affected in mild cognitive impairment.Regulation of perfusion may help to maintain brain structure and function and potentially delay conversion to dementia.

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Language(s): eng - English
 Dates: 2016-12-092017-03-102017-06-202018-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.14283/jpad.2017.23
PMID: 29405229
 Degree: -

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Project name : -
Grant ID : Fl 379-10/1 ; Fl 379-11/1
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : -
Grant ID : 0315673A ; 01EO0801 ; 01GQ1424A ; 01GQ1420B
Funding program : -
Funding organization : German Federal Ministry of Education and Research (BMBF)
Project name : -
Grant ID : -
Funding program : Hans Gerhard Creutzfeldt scholarship
Funding organization : Charite - University Medicine Berlin
Project name : -
Grant ID : -
Funding program : NeuroCure Female postdoctoral research fellowship
Funding organization : Charite - University Medicine Berlin
Project name : NeuroCure - neue Perspektiven in der Therapie neurologischer Erkrankungen / EXC 257
Grant ID : -
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)

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Title: The Journal of Prevention of Alzheimer's Disease: JPAD
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Cham : Springer International Publishing
Pages: - Volume / Issue: 5 (1) Sequence Number: - Start / End Page: 26 - 30 Identifier: ISSN: 2426-0266
CoNE: https://pure.mpg.de/cone/journals/resource/2426-0266