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  Antitumor anthraquinones from an Easter Island Sea Anemone: animal or bacterial origin?

Sottorff, I., Künzel, S., Wiese, J., Lipfert, M., Preußke, N., Sönnichsen, F. D., et al. (2019). Antitumor anthraquinones from an Easter Island Sea Anemone: animal or bacterial origin? Marine Drugs, 17(3): 154. doi:10.3390/md17030154.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-6FE0-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-6FE1-3
Genre: Journal Article

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Sottorff, Ignacio, Author
Künzel, Sven1, Author              
Wiese, Jutta, Author
Lipfert, Matthias, Author
Preußke, Nils, Author
Sönnichsen, Frank D., Author
Imhoff, Johannes F., Author
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1Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              

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 Abstract: The presence of two known anthraquinones, Lupinacidin A and Galvaquinone B, which have antitumor activity, has been identified in the sea anemone (Gyractis sesere) from Easter Island. So far, these anthraquinones have been characterized from terrestrial and marine Actinobacteria only. In order to identify the anthraquinones producer, we isolated Actinobacteria associated with the sea anemone and obtained representatives of seven actinobacterial genera. Studies of cultures of these bacteria by HPLC, NMR, and HRLCMS analyses showed that the producer of Lupinacidin A and Galvaquinone B indeed was one of the isolated Actinobacteria. The producer strain, SN26_14.1, was identified as a representative of the genus Verrucosispora. Genome analysis supported the biosynthetic potential to the production of these compounds by this strain. This study adds Verrucosispora as a new genus to the anthraquinone producers, in addition to well-known species of Streptomyces and Micromonospora. By a cultivation-based approach, the responsibility of symbionts of a marine invertebrate for the production of complex natural products found within the animalrsquo;s extracts could be demonstrated. This finding re-opens the debate about the producers of secondary metabolites in sea animals. Finally, it provides valuable information about the chemistry of bacteria harbored in the geographically-isolated and almost unstudied, Easter Island.

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Language(s): eng - English
 Dates: 2019-01-312019-02-262019-03-052019
 Publication Status: Published in print
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 Identifiers: DOI: 10.3390/md17030154
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Title: Marine Drugs
Source Genre: Journal
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Publ. Info: Basel, Switzerland : MDPI AG
Pages: 154 Volume / Issue: 17 (3) Sequence Number: 154 Start / End Page: - Identifier: ISSN: 1660-3397
CoNE: https://pure.mpg.de/cone/journals/resource/1660-3397