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  Simultaneous FMRI/CBV and EEG During Spike-Wave Seizures in WAG/Rij Rats

Mishra, A., Ellens, D., Schridde, U., Motelow, J., Purcaro, M., Hyder, F., et al. (2008). Simultaneous FMRI/CBV and EEG During Spike-Wave Seizures in WAG/Rij Rats. Poster presented at 16th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2008), Toronto, Canada.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-930C-A Version Permalink: http://hdl.handle.net/21.11116/0000-0003-930D-9
Genre: Poster

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 Creators:
Mishra, AM, Author
Ellens, DJ, Author
Schridde, U1, 2, Author              
Motelow, JE, Author
Purcaro, MJ, Author
Hyder, F, Author
Blumenfeld, H, Author
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: In absence and other generalized seizure disorders, an abnormal electrical activity termed as spike-wave discharges (SWD) is observed by EEG. fMRI during SWD in humans and animal absence epilepsy models show both increases and decreases in BOLD signals. Here we show regional BOLD increases/decreases during SWD accompanied by CBV increases/decreases in nearly the same areas for anesthetized WAG/Rij rats. Further work will be needed to determine if regions of BOLD decreases during SWD represent vascular steal, a primary neuronal mechanism, or a defect in neurovascular coupling. These findings will be important for the interpretation of various fMRI signals in human absence epilepsy.

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 Dates: 2008-05
 Publication Status: Published in print
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Title: 16th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2008)
Place of Event: Toronto, Canada
Start-/End Date: 2008-05-03 - 2008-05-09

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Title: 16th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2008)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 3621 Start / End Page: 582 Identifier: -