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  How many samples are needed to infer truly clonal mutations from heterogenous tumours?

Opasic, L., Zhou, D., Werner, B., Dingli, D., & Traulsen, A. (2019). How many samples are needed to infer truly clonal mutations from heterogenous tumours? BMC Cancer, 19(403), 1-11. doi:10.1186/s12885-019-5597-1.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-A456-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-A457-2
Genre: Journal Article

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Opasic_et_al-2019-BMC_Cancer.pdf (Publisher version), 3MB
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Opasic, Luka1, Author              
Zhou, Da1, Author              
Werner, Benjamin, Author
Dingli, David, Author
Traulsen, Arne1, Author              
Affiliations:
1Department Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445641              

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 Abstract: Modern cancer treatment strategies aim to target tumour specific genetic (or epigenetic) alterations. Treatment response improves if these alterations are clonal, i.e. present in all cancer cells within tumours. However, the identification of truly clonal alterations is impaired by the tremendous intra-tumour genetic heterogeneity and unavoidable sampling biases.

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Language(s): eng - English
 Dates: 2019-01-242019-04-112010-04-292019-04
 Publication Status: Published in print
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 Identifiers: DOI: 10.1186/s12885-019-5597-1
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Title: BMC Cancer
Source Genre: Journal
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Publ. Info: BioMed Central
Pages: - Volume / Issue: 19 (403) Sequence Number: - Start / End Page: 1 - 11 Identifier: ISSN: 1471-2407
CoNE: https://pure.mpg.de/cone/journals/resource/111000136906046