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  Comparing MRI metrics to quantify white matter microstructural damage in multiple sclerosis

Lipp, I., Jones, D. K., Bells, S., Sgarlata, E., Foster, C., Stickland, R., et al. (2019). Comparing MRI metrics to quantify white matter microstructural damage in multiple sclerosis. Human Brain Mapping, 40(10), 2917-2932. doi:10.1002/hbm.24568.

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 Urheber:
Lipp, Ilona1, 2, 3, Autor           
Jones, Derek K.2, 4, Autor
Bells, Sonya2, 5, Autor
Sgarlata, Eleonora1, 6, Autor
Foster, Catherine2, Autor
Stickland, Rachael2, Autor
Davidson, Alison E.1, 2, Autor
Tallantyre, Emma C.1, 7, Autor
Robertson, Neil P.1, 7, Autor
Wise, Richard G.2, Autor
Tomassini, Valentina1, 2, 7, Autor
Affiliations:
1Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, United Kingdom, ou_persistent22              
2Brain Research Imaging Centre, School of Psychology, Cardiff University, United Kingdom, ou_persistent22              
3Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
4Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia, ou_persistent22              
5Neurosciences and Mental Health, The Hospital for Sick Children, University of Toronto, ON, Canada, ou_persistent22              
6Department of Human Neuroscience, Sapienza University of Rome, Italy, ou_persistent22              
7Helen Durham Centre for Neuroinflammatory Disease, University Hospital of Wales, Cardiff, United Kingdom, ou_persistent22              

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Schlagwörter: Brain MRI; Diffusion; Lesions; Magnetisation transfer ratio; Multiple sclerosis; Myelin water fraction
 Zusammenfassung: Quantifying white matter damage in vivo is becoming increasingly important for investigating the effects of neuroprotective and repair strategies in multiple sclerosis (MS). While various approaches are available, the relationship between MRI‐based metrics of white matter microstructure in the disease, that is, to what extent the metrics provide complementary versus redundant information, remains largely unexplored. We obtained four microstructural metrics from 123 MS patients: fractional anisotropy (FA), radial diffusivity (RD), myelin water fraction (MWF), and magnetisation transfer ratio (MTR). Coregistration of maps of these four indices allowed quantification of microstructural damage through voxel‐wise damage scores relative to healthy tissue, as assessed in a group of 27 controls. We considered three white matter tissue‐states, which were expected to vary in microstructural damage: normal appearing white matter (NAWM), T2‐weighted hyperintense lesional tissue without T1‐weighted hypointensity (T2L), and T1‐weighted hypointense lesional tissue with corresponding T2‐weighted hyperintensity (T1L). All MRI indices suggested significant damage in all three tissue‐states, the greatest damage being in T1L. The correlations between indices ranged from r = 0.18 to r = 0.87. MWF was most sensitive when differentiating T2L from NAWM, while MTR was most sensitive when differentiating T1L from NAWM and from T2L. Combining the four metrics into one, through a principal component analysis, did not yield a measure more sensitive to damage than any single measure. Our findings suggest that the metrics are (at least partially) correlated with each other, but sensitive to the different aspects of pathology. Leveraging these differences could be beneficial in clinical trials testing the effects of therapeutic interventions.

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Sprache(n): eng - English
 Datum: 2019-02-102018-12-102019-03-012019-03-192019-07-01
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1002/hbm.24568
Anderer: Epub 2019
PMID: 30891838
PMC: PMC6563497
 Art des Abschluß: -

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Projektname : -
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Förderorganisation : Medical Research Council (MRC)
Projektname : -
Grant ID : -
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Förderorganisation : Multiple Sclerosis Society
Projektname : -
Grant ID : 104943/Z/14/Z
Förderprogramm : Wellcome Trust Strategic Award
Förderorganisation : Wellcome Trust
Projektname : -
Grant ID : 096646/Z/11/Z
Förderprogramm : Wellcome Trust Investigator Award
Förderorganisation : Wellcome Trust

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Titel: Human Brain Mapping
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: New York : Wiley-Liss
Seiten: - Band / Heft: 40 (10) Artikelnummer: - Start- / Endseite: 2917 - 2932 Identifikator: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686