English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  PAM identification by CRISPR-Cas effector complexes: diversified mechanisms and structures.

Gleditzsch, D., Pausch, P., Müller-Esparza, H., Özcan, A., Guo, X., Bange, G., et al. (2018). PAM identification by CRISPR-Cas effector complexes: diversified mechanisms and structures. RNA Biol., 18: 14, pp. 1. doi:10.1080/15476286.2018.1504546.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Gleditzsch, Daniel1, Author              
Pausch, Patrick, Author
Müller-Esparza, Hanna1, Author              
Özcan, Ahsen1, Author              
Guo, Xiaohan1, Author              
Bange, G., Author
Randau, Lennart1, Author              
Affiliations:
1Max Planck Research Group Prokaryotic small RNA Biology, Alumni, Max Planck Institute for Terrestrial Microbiology, Max Planck Society, Karl-von-Frisch-Strasse 10, D-35043 Marburg, ou_3266318              

Content

show
hide
Free keywords: -
 Abstract: Adaptive immunity of prokaryotes is mediated by CRISPR-Cas systems that employ a large variety of Cas protein effectors to identify and destroy foreign genetic material. The different targeting mechanisms of Cas proteins rely on the proper protection of the host genome sequence while allowing for efficient detection of target sequences, termed protospacers. A short DNA sequence, the protospacer-adjacent motif (PAM), is frequently used to mark proper target sites. Cas proteins have evolved a multitude of PAM-interacting domains, which enables them to cope with viral anti-CRISPR measures that alter the sequence or accessibility of PAM elements. In this review, we summarize known PAM recognition strategies for all CRISPR-Cas types. Available structures of target bound Cas protein effector complexes highlight the diversity of mechanisms and domain architectures that are employed to guarantee target specificity.

Details

show
hide
Language(s):
 Dates: 2018
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Internal
 Identifiers: eDoc: 747959
DOI: 10.1080/15476286.2018.1504546
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: RNA Biol.
  Alternative Title : RNA Biol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 18 Sequence Number: 14 Start / End Page: 1 Identifier: -