English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Aryl Sulfonium Salts for Site‐Selective Late‐stage Trifluoromethylation

Ye, F., Berger, F., Jia, H., Ford, J., Wortman, A., Börgel, J., et al. (2019). Aryl Sulfonium Salts for Site‐Selective Late‐stage Trifluoromethylation. Angewandte Chemie, International Edition, 58(41), 14615-14619. doi:10.1002/anie.201906672.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Ye, Fei1, Author              
Berger, Florian1, Author              
Jia, Hao1, Author              
Ford, Joseph1, Author
Wortman, Alan1, Author              
Börgel, Jonas1, Author              
Genicot, Christophe2, Author
Ritter, Tobias1, Author              
Affiliations:
1Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_2040308              
2Global Chemistry, UCB Medicines, UCB Biopharmaca, Braine-L'Alleud, 1420 Belgium, ou_persistent22              

Content

show
hide
Free keywords: late-stage C-H functionalization; photoredox catalysis; site selectivity; sulfonium salts; trifluoromethylation
 Abstract: Incorporation of the CF3 group into arenes has found increasing importance in drug discovery. Herein, we report the first photoredox‐catalyzed cross‐coupling of aryl thianthrenium salts with a copper‐based trifluoromethyl reagent, which enables a site‐selective late‐stage trifluoromethylation of arenes. The reaction proceeds with broad functional group tolerance, even for complex small molecules on gram scale. The method was further extended to produce pentafluoroethylated derivatives.

Details

show
hide
Language(s): eng - English
 Dates: 2019-05-292019-07-162019-08-072019-10-07
 Publication Status: Published in print
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/anie.201906672
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Angewandte Chemie, International Edition
  Abbreviation : Angew. Chem., Int. Ed.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 58 (41) Sequence Number: - Start / End Page: 14615 - 14619 Identifier: ISSN: 1433-7851
CoNE: https://pure.mpg.de/cone/journals/resource/1433-7851