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  The Benefits of Cotranslational Assembly: A Structural Perspective

Schwarz, A., & Beck, M. (2019). The Benefits of Cotranslational Assembly: A Structural Perspective. Trends in Cell Biology, 29(10), 791-803. doi:10.1016/j.tcb.2019.07.006.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-991D-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-C4EB-6
Genre: Journal Article

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 Creators:
Schwarz, Andre1, 2, Author
Beck, Martin1, 3, 4, Author              
Affiliations:
1European Molecular Biology Laboratory, Structural and Computational Biology Unit, Heidelberg, Germany, ou_persistent22              
2Collaboration for joint PhD degree between EMBL and Heidelberg University, Faculty of Biosciences, Heidelberg,Germany, ou_persistent22              
3Department of Molecular Sociology, Max Planck Institute of Biophysics, Max Planck Society, ou_3040395              
4European Molecular Biology Laboratory, Cell Biology and Biophysics Unit, Heidelberg, Germany, ou_persistent22              

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Free keywords: cotranslational assembly, orphan protein degradation, protein complexes, translation
 Abstract: The faithful assembly of protein complexes in space and time is a hallmark of cellular homeostasis. Complex assembly might be seeded already during translation, if interacting subunits are recruited to the nascent chain. Here, we review recent discoveries suggesting that such cotranslational assembly is a prominent feature throughout the proteome. It might contribute to the efficiency and efficacy of assembly and occurs in coordination rather than competition with chaperones. We discuss how cotranslational assembly structurally contributes to the organizational order of assembly pathways and their surveillance. Taken together, these novel insights suggest that cotranslational assembly is intimately linked with the regulation of protein abundance, stability, and activity, offering an attractive explanation for many cellular phenomena.

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Language(s): eng - English
 Dates: 2019-08-162019-10-01
 Publication Status: Published in print
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

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Title: Trends in Cell Biology
  Other : Trends Cell Biol.
Source Genre: Journal
 Creator(s):
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Publ. Info: Cambridge, UK : Elsevier Current Trends
Pages: - Volume / Issue: 29 (10) Sequence Number: - Start / End Page: 791 - 803 Identifier: ISSN: 0962-8924
CoNE: https://pure.mpg.de/cone/journals/resource/954925580131